摘要
目的探讨慢性乙型肝炎合并肝脂肪变的相关因素及发生脂肪变对肝脏炎症和纤维化的影响。方法病例选自2008年7月至2009年12月有肝活组织检查的慢性乙型肝炎患者306例,肝组织中脂肪变肝细胞<5%小叶内肝细胞者为慢性乙型肝炎组,共有165例。脂肪变肝细胞>5%小叶内肝细胞者为慢性乙型肝炎合并脂肪肝组,共有141例。用t检验比较两组患者血糖、血脂和体重指数的差异,对肝脂肪变可能相关因素如性别、年龄、体重指数、血脂、血糖等进行Logistic多因素回归分析,用χ2检验分析不同程度的肝脂肪变对肝脏炎症、纤维化的影响。结果高体重指数和男性是慢性乙型肝炎患者合并肝细胞脂肪变的危险因素,脂肪变的程度与肝脏炎症和纤维化分级无相关性(χ2=6.374,P=0.605和χ2=8.428,P=0.393),差异无统计学意义。结论慢性乙型肝炎合并肝脂肪变主要与高体重指数及男性相关,肝脏脂肪变并不加重肝组织的炎症及纤维化。
Objective To identify factors associated with hepatic steatosis in chronic hepatitis B(CHB) patients and clarify the affects of hepatic steatosis to liver inflammation and fibrosis.Methods 306 consecutive CHB patients with satisfied liver biopsy were included in this study,who were admitted to our hospital from July 2008 to December 2009.165 cases with steatosis<5% in hepatocytes were divided to CHB group.141 cases with steatosis >5% in hepatocytes were divided to CHB associated with steatosis group.Association of gender,age,body mass index(BMI),blood lipid and blood sugar with hepatic steatosis were analyzed by logistic regression.The relationship of steatotic degree with hepatic inflammation and fibrosis were analyzed.Results Higher BMI and male sex were the factors associated with steatosis in CHB [OR(95% CI)were 1.269(1.161-1.387)and 1.938(1.089-3.447),respectively].The degree of hepatic steatosis has no relation to the grades of inflammation and fibrotic stages(χ2=6.374,P=0.605 and χ2=8.428,P=0.393).Conclusions Higher BMI and male sex are the factors associated with steatosis in CHB.Liver steatosis does not aggravate hepatic inflammation and fibrosis.
出处
《中华临床医师杂志（电子版）》
CAS
2011年第16期4636-4640,共5页
Chinese Journal of Clinicians(Electronic Edition)
基金
烟台市科学技术发展计划项目(2009151)
关键词
肝炎
乙型
慢性
脂肪肝
肝硬化
炎症
Hepatitis B,chronic
Fatty liver
Liver cirrhosis
Inflammation
