摘要
目的:通过观察小鼠灌胃给予生脉散后对抗心肌缺血的正交试验,来探求生脉散中各组分之间的最佳配比。方法:小鼠按分组灌胃分别给予不同配比的生脉散20ml/kg/d,采用Ⅱ导联心电图,观察腹腔给予垂体后叶素前后心电图的变化情况。结果:通过正交试验,我们求出人参为18g、麦冬为18g、五味子为3g的生脉散配比可使心电图中J点抬高和心率减慢幅度最小,能更好的对抗垂体后叶素导致的心肌缺血作用。结论:正交试验结果提示,优化组(人参18g,麦冬18g,五味子3g)的生脉散的配比对心肌缺血的保护作用较好。
Objective:To observe the protective effect of Shengmaisan on the myocardial ischemic injury in mice and explore the best proportion of different ingredients Shengmaisan.Methods:Different ingredient Shengmaisan were given to mice with 20ml/kg/d,then inject pituitrin after the last time and then look the change of cardiograph.Results:In the orthogonal experiment, number9(18:18:3)has the lest change in the J point.Conclusion:The proportion of18:18:3in shengmaisan has a better protective effect against myocardial ischemic injury.
出处
《黑龙江医药》
CAS
2009年第6期788-791,共4页
Heilongjiang Medicine journal
关键词
生脉散
心肌缺血
垂体后叶素
正交试验
Shengmaisan
Myocardial Ischemic Injuary
Pituitrin
Othogonal Experiment
