摘要
目的探讨脑白质疏松症(LA)患者认知功能、血浆同型半胱氨酸(Hcy)水平与颈动脉血流动力学指标的关系。方法测试LA患者认知损害水平,根据结果分为三组,分别为痴呆组、轻度认知功能障碍组和无认知功能障碍组。根据三组患者的血浆Hcy水平及颈部血管超声血流动力学指标进行相关性分析。结果痴呆组患者的血浆Hcy水平较轻度认知功能障碍组与无认知功能障碍组增高(P<0.05),双侧颈内动脉阻力指数(RI)、搏动指数(PI)亦较轻度认知功能障碍组与无认知功能障碍组增高(P<0.05)。结论 LA患者不同水平认知功能与血浆Hcy水平和颈部血管超声变化存在相关性,血浆Hcy水平越高,RI和PI越高,则认知损害越重。
Objective To investigate the relationship between the cognitive function with plasma homocysteine(Hcy)level as well as carotid artery blood flow parameters among patients with leukoaraiosis.Methods Patients with leukoaraiosis were divide into the dementia group,the mild cognitive impairment group,and the normal group according to their cognitive function.The relativity was analyzed according to their plasma Hcy levels and carotid ultrasound hemodynamic parameters.Results The level of the plasma Hcy in the dementia group was significantly higher than that in the mild cognitive impairment group and the normal group(P<0.05).The resistant index(RI)and pulsate index(PI)in the dementia group were also significantly higher than that in the mild cognitive impairment group and the normal group(P<0.05).Conclusion There is a correlation between different cognitive level and plasma Hcy level as well as carotid ultrasound parameters among patients with leukoaraiosis.The higher the plasma Hcy level as well as RI and PI,the more severe the cognition impaired.
出处
《神经病学与神经康复学杂志》
2010年第1期22-25,共4页
Journal of Neurology and Neurorehabilitation
