摘要
目的 探讨凋亡抑制蛋白survivin在子宫腺肌瘤在位内膜、异位内膜的表达 ,研究以survivin为核心的细胞凋亡、增殖及血管生成机制与子宫腺肌瘤发病的相关性。方法 采用免疫组化法检测子宫腺肌瘤在位内膜、异位内膜及正常对照组内膜中survivin ,PCNA ,endoglin蛋白表达。 结果 子宫腺肌瘤异位内膜组survivin蛋白的表达和微血管密度显著高于在位内膜组和异位内膜组 (P <0 .0 1) ,增殖期宫内膜、分泌期宫内膜survivin蛋白表达与endoglin蛋白表达呈显著相关性。 结论 survivin的过度表达可能参与了子宫腺肌瘤的发病过程 。
Objective To investigate the expression of survivin in normal human endometrium, and adenomyosis in order to study the function and relativity of apoptosis, cell proliferation and angiogenesis in the course of adenomyosis.Methods Specimens of normal endometrium, ectopic endometrial tissue and eutopic endometrial tissue in adenomyosis were obtained for immunohistochemical survivin, PCNA and endoglin analyses.Results The expression of survivin and microvessel density in ectopic endometrial tissue of adenomyosis was significantly higher than that of normal endometrium and eutopic endometrial tissue in adenomyosis ( P < 0.01 ), survivin expression was significantly associated with endoglin expression in endometrium of proliferate phase and secretary phase( r = 0.612 , P < 0.01 ).Conclusion The overexpression of survivin and survivin collected apoptosis and angiogenesis mechanism might play a pathogenic role in the development of adenomyosis.
出处
《肿瘤防治研究》
CAS
CSCD
2004年第7期400-402,F003,共4页
Cancer Research on Prevention and Treatment
