摘要
目的:研究芍药苷对内脏敏感性肠易激综合征(IBS)的治疗作用。方法:经肠道连续6天给予冰醋酸或芥末油,分别建立冰醋酸或芥末油大鼠内脏高敏感性IBS模型,灌胃曲美布丁或芍药苷高、中、低剂量药液,每天1次连续3天,观察各组大鼠肠道内扩张引起腹部抬起和背部拱起的容量阈值,记录大鼠结肠电频率、峰电位、峰峰值和面积。结果:曲美布丁及芍药苷中剂量给药后大鼠肠敏感性显著改善,明显降低两种模型大鼠腹部抬起和背部拱起阈值,降低结肠电频率、峰电位、峰峰值及峰面积。结论:芍药苷可通过降低肠道敏感性,改善结肠电生理活动来治疗内脏高敏感性IBS模型大鼠。
Objective:To study the treatment of Paeoniflorin on Visceral Hypersensitivity Irritable Bowel Syndrome.Method:Acetic acid or mustard was injected respectively into the intestine for six days to establish the acetic or mustard visceral hypersensitivity IBS model,then Bifid Triple Viable Capsules and different dosages of Paeoniflorin were given by gavage,one time in a day,for 3 days,to observe the threshold values of abdominal raising and back arching of rats in each group caused by intestinal expansion,and to record the frequency,peak-nadir value,area and peak value of the enteric electrical activity.Result:The intestinal sensitivity was significantly improved,the threshold values of abdominal raising and back arching were significantly decreased and the frequency,peak-nadir value,area and peak value were also decreased after the administration of Bifid Triple Viable Capsules and middle dosage of paeoniflorin.Conclusion:Paeoniflorin is able to cure model rats by decreasing intestinal sensitivity and improving enteric electrical activity.
出处
《中药与临床》
2011年第6期38-41,共4页
Pharmacy and Clinics of Chinese Materia Medica
基金
国家自然科学基金项目No39970928
中韩国际合作项目专利申请号:201010574295.5
关键词
芍药苷
肠易激综合征
肠敏感性
肠肌电
Paeoniflorin
IBS
Intestinal Sensitivity
Enteric Electrical Activity
