摘要
目的探讨维持性血液透析患者桡动脉增强指数(augmentation index,AI)与腹主动脉钙化指数(abdominal aortic calcification,AAC)、颈动脉内膜厚度(intima-media thickness,IMT)和心脏功能的相关性及其影响因素。方法选取大连医科大学附属第一医院血液净化中心41名维持性血液透析患者。HEM9001AI测定AI,半定量计算AAC,彩色多普勒测定IMT及左心室舒张末内径(LVDd)、左心室后壁厚度(LVPW)、左心室重量指数(LVMI)、左室舒张末期室间隔厚度(IVS)、左房室瓣口舒张早期E波的峰值流速(E)和舒张晚期A波的峰值流速(A)比值(E/A)、射血分数(EF)。采用SPSS16.0统计软件进行分析,进行Pearson相关分析,多元线性回归分析AI与各自变量之间的关系。结果 AI与AAC正相关性(r=0.435,P<0.05),与IMT正相关性(r=0.458,P<0.05),与LVDd(r=0.537,P<0.01),LVPW(r=0.469,P<0.05),LVMI(r=0.59,P<0.01),IVS(r=0.478,P<0.01)正相关,而与舒张功能指标E/A(r=-0.523,P<0.01)及EF(r=-0.534,P<0.01)负相关。多元线性回归分析结果性别、性别、年龄、体质量指数(BMI)、平均动脉压、AAC、IMT以及LVDd、LVPW、LVMI、IVS是AI的影响因素。结论维持性血液透析患者桡动脉增强指数与腹主动脉钙化指数、颈动脉内膜厚度和心脏功能具有相关性,多种因素影响AI的改变。
Objective To approach the correlation of radial augmentation index(AI) with abdominal aortic calcification(AAC),intima-media thickness(IMT) and cardiac function in maintenance hemodialysis patients.Methods A total of 41 maintenance hemodialysis patients treated in the hemodialysis center of the First Hospital of Dalian Medical University were enrolled and investigated.Augmentation index was measured by HEM9001 tonometer,and semiquantification of calcium deposit in abdominal aorta as the percentage of aortic calcification volume(% ACV) was detected by spiral CT.We determined IMT,LVDd,LVPW,LVMI,IVS,E/A and EF by color Doppler sonography.Data are presented as mean ± D.Relationships between variables were assessed by Pearson correlation analysis and multiple liner regression.Results Our study showed that AI significantly correlated to AAC(r=0.435,P < 0.05) and IMT(r=0.458,P < 0.05).AI also positively correlated to LVDd(r=0.537,P < 0.01),LVPW(r=0.469,P < 0.05),LVMI(r=0.59,P < 0.01) and IVS(r=0.478,P < 0.01),and negatively correlated to E/A(r=-0.523,P < 0.01) and EF(r =-0.534,P < 0.01).Multiple liner regression showed that gender,age,BMI,MPA,AAC,IMT,LVDd,LVPW,LVMI and IVS were the factors affecting AI.Conclusion Radial augmentation index correlates to AAC,IMT and cardiac function in maintenance hemodialysis patients.
出处
《中国血液净化》
2012年第9期493-496,共4页
Chinese Journal of Blood Purification
