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维持性血液透析患者颈动脉粥样硬化及相关因素分析 被引量:9

Studies on carotid artery atherosclerosis and its related factors in maintenance hemodialysis patients
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摘要 目的了解慢性肾衰竭维持性血液透析(maintenance hemodialysis,MHD)患者颈动脉粥样硬化(carotid artery atherosclerosis,CAS)发生情况并分析其相关影响因素。方法收集55例MHD患者。采用高分辨B型超声多普勒方法测定其双侧颈动脉解剖,按斑块有无分为斑块阳性组和斑块阴性组。对2组各数据进行比较,并对斑块产生的各危险因素进行Logistic回归分析。结果 55例MHD患者中,颈动脉斑块发生率为69.09%。与斑块阴性组相比,阳性组患者颈动脉血管内皮厚度(即内膜-中层厚度,intima-media thickness,IMT)明显增加(P=0.001)。2组患者在年龄(P<0.001)、血红蛋白(hemoglobin,Hb)水平(P=0.01)和C反应蛋白(Creactive protein,CRP)水平(P=0.002)上差异有显著性(P均<0.05)。Logistic回归分析结果显示高龄(β=1.102,P=0.014)、高CRP水平(β=0.138,P=0.026)是颈动脉斑块发生的主要危险因素。结论 MHD患者具有较高的CAS发生率,其主要危险因素是高龄、高CRP水平。 Objective To understand the formation of carotid artery atherosclerosis(CAS) and its potential causes in maintenance hemodialysis(MHD) patients.Methods We recruited 55 MHD cases and measured their physical dimensions of bilateral carotid arteries by using high resolution ultrasonography.They were then assigned into plaque positive group or plaque negative group.Data were compared between the two groups.Logistic regression analysis was performed to disclose the potential factors leading to plaque generation.Results Atherosclerotic plaque was found in 69.09% of the 55 MHD cases.The intima-media thickness(IMT) of the carotid arteries was significant larger in plaque positive group than in negative group(P=0.001).Other significant differences between the two groups included age(P=0.000),hemoglobin(Hb) level(P=0.01) and C reactive protein(CRP) level(P=0.002).Logistic regression analysis indicated that older age(?1.102,P=0.014) and higher CRP level(?0.138,P=0.026) were the two major contribution factors for atherosclerotic plaque formation.Conclusions MHD patients have higher potential of CAS.Older age and higher CRP level are the two major risk factors for atherosclerotic plaque formation in carotid artery.
出处 《中国血液净化》 2012年第6期318-320,共3页 Chinese Journal of Blood Purification
关键词 维持性血液透析 颈动脉 粥样硬化 危险因素 Maintenance hemodialysis Carotid artery Atherosclerosis Risk factor
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  • 1刘虹,彭佑铭,高雷,刘伏友,刘映红.维持性血液透析患者颈动脉硬化及相关因素分析[J].中国血液净化,2005,4(2):89-92. 被引量:5
  • 2杨霓芝,左琪,桂定坤,王立新,包昆,林启展,刘旭生.中药对血透患者营养不良-炎症综合征的影响[J].中国中西医结合肾病杂志,2006,7(12):704-707. 被引量:27
  • 3郑法雷.尿毒症性营养不良-恶液质综合征的发病机制与防治[J].中国中西医结合肾病杂志,2007,8(1):1-3. 被引量:12
  • 4[1]Boushey CJ,Beresford SA,Omenn GS,et al.A quantitative assessment of plasma homocysteine as a risk factor for vascular disease.Probable benefits of increasing folic acid intakes.JAMA,1995,274(13):1049-1057
  • 5[2]Yu HH,Joubran R.Agreemeet among four homocysteine assays and resuits in patients with coronary atherosclerosis and controls.Clin Chem,2000,46(3):258-264
  • 6[4]Jacobsen DW.Cardiovascular disorders (risk assessment).Clin Chem,1993,65(2):367-373
  • 7[5]Perna AF,Ingrosso D,Satta E,et al.Metabolic consequences of hyperhomocysteinemia in uremia.Am-J-Kidney-Dis,2001,38(4):s85-90
  • 8[6]Tremblay R,Bonnardeaux A,Geadah D,et al.Hyperhomocysteinemia in hemodialysis patients:Effects of 12-month supplementation with hydrosoluble vitamins.Kidney Int,2000,58(2):851-858
  • 9[7]Pignoli P,Tremoli E,poli A,et al.Intimal plus medial thickness of the artery wall:a direct measurement with ultrasound imaging.Circulation,1986,74(6):1399-1406
  • 10[8]Tawakol A,Omland T.Hyperhomocysteinemia is associated with impaired endothelium-dependent vasodilation in humans.Circulation ,1997,95(5):1119-1121

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