摘要
[目的]探讨使用黄连素联合二甲双胍治疗胰岛素抵抗多囊卵巢综合征患者对BMI、LH、LH/FSH、T、HOMA(IR)及排卵率的影响。[方法]将58例患者随机分为对照组和治疗组两组,对照组给予二甲双胍,1500mg,分3次服用,口服3个月;治疗组在对照组基础上加用黄连素0.5g,3次/d,连用3个月。观察治疗前后体重指数、性激素水平、胰岛素抵抗及排卵率的变化。[结果]与治疗前比较,两组BMI、LH、LH/FSH、T、HOMA(IR)均明显下降,排卵率明显升高,差别均有统计学意义(P<0.05);治疗后与对照组比较,治疗组排卵率升高及其余指标降低明显,差异有统计学意义(P<0.05)。[结论]黄连素联合二甲双胍可以有效降低胰岛素抵抗多囊卵巢综合征肥胖患者的体重指数、性激素水平及胰岛素抵抗,提高排卵率。
[Objective]To investigate of therapeutic effect of berberine combined with diformin for women with polycystic ovary syndrome and insulin resistance.[Methods]Fifty-six women with polycystic ovary syndrome and insulin resistance were divided into two groups by random and treated with diformin(group A) or berberine combined with diformin(group B) respectively for three months,to observe the change of body mass index,sex hormone,insulin resistance and the rate of ovulating after treatment.[Results]After three months treatment,the BMI,LH,LH/FSH,T and HOMA(IR)were decreased greatly and significant difference was found between two groups.In two groups,the ovulate rate was increased greatly and significant difference was found after three months treatment.[Conclusion]Berberine combined with diformin can improve the condition of BMI and IR more effectively,increasing the rate of ovulating condition.
出处
《浙江中医药大学学报》
CAS
2011年第5期713-715,共3页
Journal of Zhejiang Chinese Medical University
