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食管鳞癌患者围手术期外周血循环肿瘤细胞检测的临床意义 被引量：4

Clinical Significance of Circulating Tumor Cells in Peripheral Blood of Patients with Esophageal Squamous Cell Carcinoma During Perioperative Period
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摘要 [目的]探讨食管鳞癌患者围手术期外周血中的循环肿瘤细胞(CTC)检出水平的意义及预后价值.[方法]检测48例食管鳞癌患者术前1 d、术后7 d外周静脉血CTC,分析术前CTC检出阳性水平与临床病理生理特征的关系,分析术前、术后CTC检出阳性水平与术后无进展生存时间(PFS)的关系.[结果]术前CTC不同检出水平与细胞分化程度、淋巴结转移状态及p- TNM分期关系密切.肿瘤分化程度越低(χ2=9.636,P=0.008)、淋巴结转移越多(χ2=4.218,P=0.040)、p-TNM分期越晚(χ2=8.392,P=0.004),CTC检出阳性率越高.术前、术后血CTC检出阳性组的术后PFS(均为20个月)较术前、术后检出阴性组低(均为13个月),且差异均有显著性(均P<0.01).[结论]食管鳞癌患者外周血CTC的检出水平可以反应肿瘤的进展程度及作为预后判断的指标,CTC水平越高可能提示预后不良.
作者 李军 王伟 乔媛媛 尚立群 李学昌 文锋 刘军强
机构地区 南方医科大学
出处 《医学临床研究》 CAS 2012年第6期-,共3页 Journal of Clinical Research
关键词 癌 鳞状细胞 食管肿瘤/外科学 肿瘤循环细胞
分类号 R735.1 [医药卫生—肿瘤]
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参考文献1

二级参考文献14

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共引文献8

同被引文献31

  • 1Dena Marrinucci,Kelly Bethel,Richard H. Bruce,Douglas N. Curry,Ben Hsieh,Mark Humphrey,Robert T. Krivacic,Joan Kroener,Lindsay Kroener,Andras Ladanyi,Nicole H. Lazarus,Jorge Nieva,Peter Kuhn.Case study of the morphologic variation of circulating tumor cells[J]. Human Pathology . 2007 (3)
  • 2T Fehm,EF Solomayer,S Meng,T Tucker,N Lane,J Wang,G Gebauer.Methods for isolating circulating epithelial cells and criteria for their classification as carcinoma cells[J]. Cytotherapy . 2005 (2)
  • 3Guojun Cao,Guang Yang,Zhaohui Liu,Xuemei Liu,Jie Zhang,Dajin Zhang,Nongle Liu,Hongmei Ding,Ming Fan,Beifen Shen,Ningsheng Shao.Identification of the RNA chaperone activity of recombinant human tumor necrosis factor alpha in vitro[J]. Biochemical and Biophysical Research Communications . 2005 (2)
  • 4Zhian Liu,Ming Jiang,Jianhua Zhao,Huangxian.Circulating Tumor Cells in Perioperative Esophageal Cancer Patients: Quantitative Assay System and Potential Clinical Utility. Clinical Cancer Research . 2007
  • 5W. Jeffrey Allard,Jeri Matera,M. Craig Miller,Madeline Repollet,Mark C. Connelly,Ch,ra Rao,Arjan G. J. Tibbe,Jonathan W. Uhr,Leon W. M. M. Terstapp.Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases. Clinical Cancer Research . 2004
  • 6任传利,何平,张金强,乔媛媛,王伟,周兰萍,文峰,赵平,赵晓航.8号和20号染色体拷贝数改变辅助食管癌外周血循环肿瘤细胞鉴定[J].中国肿瘤,2008,17(6):513-517. 被引量：9
  • 7何平,王伟,任传利,乔媛媛,张金强,文峰,周兰萍,刘芳,赵晓航.负性筛选策略与食管鳞癌循环肿瘤细胞检测[J].癌症进展,2008,6(4):402-408. 被引量：2
  • 8张惠静,毕颖楠,郝敦玲.循环肿瘤细胞检测技术的发展现状及展望[J].中国测试,2010,36(5):1-4. 被引量：3
  • 9李鹏,张澍田.早期食管癌的内镜诊断[J].中华消化内镜杂志,2013,30(1):8-9. 被引量：20
  • 10刘涛,李涛.食管癌的手术治疗及非手术治疗研究进展[J].医学综述,2016,22(3):505-507. 被引量：11

引证文献4

二级引证文献13

医学临床研究
2012年 第6期

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