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孕中期血清学唐氏筛查在高龄孕妇中的应用价值 被引量:10

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摘要 目的探讨高龄孕妇(≥35岁)进行血清学唐氏筛查的价值及其在产前诊断中的意义。方法对19 813例15~20周孕妇进行血清生化标志物甲胎蛋白(AFP)、游离人绒毛膜促性腺激素(F-βHCG)及游离雌三醇(uE3)浓度检测,并随访所有唐氏筛查孕妇的妊娠结局。结果唐氏筛查孕妇19 813例,检出高风险孕妇1 092例,筛查阳性率为5.51%,其中高龄高风险孕妇289例,筛查阳性率31.41%,高龄孕妇筛查阳性率明显高于适龄孕妇。随访妊娠结局,诊断唐氏儿16例,其中高龄孕妇9例(唐氏筛查结果均为高风险)。结论高龄孕妇行血清学唐氏筛查,根据筛查结果进行产前诊断,可以减少介入性产前诊断手术,减轻孕妇的紧张焦虑心理。
出处 《宁夏医学杂志》 CAS 2012年第8期766-767,共2页 Ningxia Medical Journal
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