泮托拉唑治疗消化性溃疡并发上消化道出血150例被引量：2

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摘要目的探讨泮托拉唑治疗消化性溃疡并发上消化道出血临床特点。方法收集2009年1月至2010年1月我院治疗的PUCH病例90例,收集之前在我院治疗的60例PUCH病例作为对照组,分析两组的临床疗效。结果泮托拉唑观察组显效率70.0%(63/90),总有效率94.4%(85/90),止血平均需(1.6±0.4)d,总不良反应发生率为1.1%,均显著优于对照组,组间差异具有显著性(P<0.05)。结论泮托拉唑治疗消化性溃疡并发上消化道出血较西咪替丁具有优越性。

作者赵春林李仙琼

机构地区攀枝花市中西医结合医院消化科

出处《现代诊断与治疗》 CAS 2012年第5期524-525,共2页 Modern Diagnosis and Treatment

关键词奥美拉唑胃体溃疡老年再出血

分类号 R573.1 [医药卫生—消化系统]

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1上海市卫可安临床协作组.潘妥拉唑钠注射液治疗消化性溃疡合并上消化道出血多中心临床研究[J].中华消化杂志,2005,25(4):233-235. 被引量：67
2杨莉,肖英莲,胡品津,陈旻湖,林金坤.三种不同剂量埃索美拉唑对健康志愿者胃内pH值的影响[J].中华消化杂志,2009,29(2):79-81. 被引量：9
3罗小平.奥美拉唑与泮托拉唑治疗消化性溃疡性伴出血的疗效比较[J].西藏医药,2011,32(2):23-24. 被引量：9
4陈会松,叶国良,程德希,盛红,谢韵琴.质子泵抑制剂干预疗程对非甾体类抗炎药溃疡性再出血的影响[J].实用医学杂志,2009,25(11):1769-1770. 被引量：18
5陈世川.泮托拉唑治疗消化性溃疡并出血45例疗效观察[J].吉林医学,2011,32(4):687-688. 被引量：7

二级参考文献25

1施文,王永铭,李端,李少丽,颜敏,陈斌艳,程能能.非甾体类抗炎药不良反应43年间的国内文献源分析[J].复旦学报（医学版）,2004,31(5):527-531. 被引量：17
2Johnson DA, Stacy T, Ryan M, et al. A comparison of esomeprazole and lansoprazole for control of intragastric pH in patients with symptoms of gastro-oesophageal reflux disease. Aliment Pharmacol Ther, 2005, 22 : 129-134.
3Hunt RH, Amstrong D, James C, et al. Effect on intragastric pH of a PPI with a prolonged plasma half-life: comparison between tenatoprazole and esomeprazole on the duration of acid suppression in healthy male volunteers. Am J Gastroenterol, 2005,100: 1949-1956.
4Shimatani T, Inoue M, Kuroiwa T, et al. Acid-suppressive efficacy of a reduced dosage of rabeprazole:comparison of 10 mg twice daily rabeprazole with 20 mg twice daily rabeprazole, 30 mg twice daily lansoprazole, and 20 mg twice daily omeprazole by 24-hr intragastric pH-metry. Dig Dis Sci, 2005, 50: 1202-1206.
5Fackler WK, Vaezi MF,Riehter JE. Ambulatory gastric pH monitoring: proper probe placement and normal values. Aliment Pharmacol Ther, 2001, 15:1155 1162.
6Katz PO, Castell DO, Chen Y, et al. Intragastric acid suppression and pharmacokinetics of twice-daily esomeprazole: a randomized, three-way crossover study. Aliment Pharmacol Ther, 2004, 20:399-406.
7Wider-Smith C, Lind T, Lundin C, et al. Acid control with esomeprazole and lansoprazole:a comparative dose-response study. Scand J Gastroenterol, 2007, 42: 157-164.
8Metz DC, Ferron GM, Panl J, et al. Proton pump activation in stimulated parietal cells is regulated by gastric acid secretory capacity: a human study. J Clin Pharmacol, 2002, 42:512-519.
9Katsube T, Adachi K, Kawamura A, et al. Helicobacter pylori infection influences nocturnal gastric acid breakthrough. Aliment Pharmacol Ther, 2000,14 : 1049-1056.
10Tutuian R, Katz PO, Castell DO, et al. Noclurnal acid breakthrough: pH, drugs and bugs. Eur J Gastroenterol Hepatol, 2004, 16: 441-443.