摘要
目的探讨加巴喷丁用于经前路颈椎手术的超前镇痛作用。方法选择ASAI～Ⅱ级40例择期经前路颈椎手术患者,随机分成两组,G组(n=20)于手术开始前2h口服加巴喷丁胶囊300mg,C组(n=20)于手术开始前2h口服维生素E胶囊。所有患者在手术结束后1h、4h、8h、12h及24h时进行疼痛视觉模拟评分(VAS)情况;采用Ramsay镇静评分评价患者的镇静情况;观察可能出现的恶心、呕吐、嗜睡、眩晕、呼吸抑制等不良反应。结果 G组术后1h、4h及8h VAS评分均低于C组(P<0.05);与C组比较,G组术后恶心、呕吐发生率更低(P<0.05);嗜睡、眩晕及呼吸抑制的发生率在两组相似。结论加巴喷丁超前镇痛可以增强经前路颈椎手术后的镇痛效果,能降低术后恶心呕吐发生率的作用。
Objective To evaluate the efficacy of preemptive analgesia with gabapentin for oral use in anterior approaches for cervical spondylotic myelopathy.Methods 40 patients ASA I ~ Ⅱ grade aged 21~70 undergoing laparoscopic cholecystectomy were randomly divided into two groups(n=20): Group 1,the gabapentin group(G) and group 2,the C group.The G group were given a bolus of 300mg gabapentin for oral use 2 hours before operation while the C group were given a bolus of vitamine E for oral use 2 hours before before operation.The pain scores VAS(visual analog scale),Ramsay sedation score,nausea,vomiting,drowsiness,giddiness,Respiratory depression and other adverse reactions were recorded in1,4,8,12,and 24 hour postoperation respectively.Results In group G,the VAS score were lower than group C at the 1 hour postoperation,4 hour postoperation and 8 hour postoperation(P<0.05).The complaint of nausea,vomiting in group G were lower than group C(P<0.05).There were no differences in complaint of drowsiness,giddiness,Respiratory depression between the two groups.Conclusion Preemptive analgesia with gabapentin via oral administration can effectively improve the epidural analgesia effect and decrease the complaint of postoperative nausea and vomiting.
出处
《四川医学》
CAS
2012年第11期1920-1922,共3页
Sichuan Medical Journal
关键词
加巴喷丁
前路颈椎手术
超前镇痛
gabapentin
anterior approaches for cervical spondylotic myelopathy
preemptive analgesia
