摘要
肝脏纤维化发病机制目前尚未完全明确,近年研究发现非特异性免疫和特异性免疫细胞均可对肝脏星状细胞产生调节作用,这些研究结果表明肝脏内各种免疫细胞的调节最终会影响肝脏疾病的进程,在肝纤维化的不同阶段发挥重要的作用,而肝星状细胞反过来也为免疫细胞的募集、激活创造了良好的微环境条件。
Pathogenesis of liver fibrosis is not yet entirely clear.Recent research found that innate and adaptive immune cells can initiate liver fibrosis by regulating hepatic stellate cells.These findings suggest that a variety of immune cells in the liver will eventually affect the progression of liver disease,and play vital role in different stages of liver fibrosis.In turn,hepatic stellate cells support a favorable micro-environmental conditions for immune cells recruitment and activation.
出处
《临床肝胆病杂志》
CAS
2012年第1期74-77,共4页
Journal of Clinical Hepatology
关键词
肝硬化
免疫力
肝星状细胞
liver cirrhosis
immunity
hepatic stellate cell
