期刊文献+

Ras相关区域家族基因启动子甲基化改变与肿瘤发生相关性的研究进展 被引量:2

原文传递
导出
摘要 Ras相关区域家族(Ras association domain family,RASSF)基因,作为肿瘤抑癌基因,具有调节细胞周期、凋亡、维持微管稳定的作用,但具体分子作用机制尚未明确.本文综合国内外最新研究成果,对RASSF家族基因研究进展做一综述,探讨其对肿瘤发生以及对肿瘤治疗新策略的指导意义.
出处 《中华临床医师杂志(电子版)》 CAS 2012年第16期4835-4838,共4页 Chinese Journal of Clinicians(Electronic Edition)
  • 相关文献

参考文献51

  • 1Downward J.Targeting RAS signalling pathways in cancer therapy,2003.
  • 2Dammann R;Li C;Yoon JH.Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3,2000.
  • 3Van der Weyden L;Adams DJ.The Ras-association domain family(RASSF)members and their role in human tumourigenesis,2007.
  • 4Lerman MI;Minna JD.The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3:identification and evaluation of the resident candidate tumor suppressor genes.The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium,2000.
  • 5Burbee DG;Forgacs E;Zchbauer-Müller S.Epigenetic inactivation of RASSF1A in lung and breast cancer and malignant phenotype suppression,2001.
  • 6Calvisi DF;Evert M;Dombrowski F.Pathogenetic and prognostic significance of inactivation of RASSF proteins in human hepatocellular carcinoma,2012.
  • 7Pelosi G;Fumagalli C;Trubia M.Dual role of RASSF1 as a tumor suppressor and an oncogene in neurodocrine tumors of the lung,2010.
  • 8Vos MD;Ellis CA;Bell A.Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis,2000.
  • 9Li J;Wang F;Protopopov A.Inactivation of RASSF1C during in vivo tumor growth identifies it as a tumor suppressor gene,2004.
  • 10Amaar YG;Minera MG;Hatran LK.Ras association domain family 1C protein stimulates human lung cancer cell proliferation,2006.

共引文献1

同被引文献26

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部