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降低异基因造血干细胞移植术后白血病复发的研究进展

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摘要 异基因造血干细胞移植(allo-HSCT)是目前治疗多种恶性血液系统疾病的有效手段.50％ ～ 70％白血病患者通过allo-HSCT获得了治愈.但是移植后白血病复发仍是造血干细胞移植后白血病患者常见的死亡原因之一,严重影响allo-HSCT的预后和疗效.根据国际骨髓移植登记处(IBMTR)的统计,allo-HSCT后近30％的白血病患者死于白血病复发,而自体干细胞移植复发率高达70％,HLA单倍体相合造血干细胞移植复发率也高达30％～70％.如何提高allo-HSCT治疗白血病的治疗效果、降低移植后白血病复发是目前人们关注的热点和重点,近年学者们从不同方面进行了积极的探索和研究,本文就allo-HSCT术后白血病复发因素及降低术后白血病复发策略和措施取得的进展进行综述.
作者 孙璨 吴秉毅
机构地区 南方医科大学珠江医院血液科
出处 《中华临床医师杂志（电子版）》 CAS 2012年第18期143-145,共3页 Chinese Journal of Clinicians(Electronic Edition)
关键词 白血病患者 AML 清髓性 预处理 前处理 异基因造血干细胞移植 髓性白血病 HSCT GVL 残留白血病细胞 供者淋巴细胞输注 外周血干细胞移植 白血福恩 抗癌药 白消安 肿瘤负荷 总生存率
分类号 R733.7 [医药卫生—肿瘤]
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参考文献26

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共引文献49

中华临床医师杂志（电子版）
2012年 第18期

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