摘要
目的 :探讨不同比例、剂量无水乙醇平阳霉素碘化油乳剂栓塞犬肝动脉的效果 ,了解栓塞后肝肾功能变化及栓塞区肝细胞、胆道的损伤情况 ,为临床推广运用提供依据。方法 :以健康犬作为实验对象 (n =12 ) ,将不同比例、剂量无水乙醇平阳霉素碘化油乳剂及对照组平阳霉素碘化油乳剂经超选择注入不同犬肝动脉一远端分支内 ,术前、术后监测血常规、肝肾功能 ,术后复查肝动脉造影、CT并处死实验犬进行肝组织学检查。结果 :术后复查肝动脉造影示靶肝动脉均明确闭塞。 2∶1组对胆道的损伤较重 ,1∶2组对肝细胞的损伤较重 ,而 1∶1组对肝细胞和胆道的损伤相对较轻。对照组对肝细胞、胆道的损害均较重。肝功能均呈一过性损害 ,术后 1～ 3wk逐渐恢复正常水平。结论 :无水乙醇平阳霉素碘化油乳剂能有效闭塞靶血管 ,1∶1组无水乙醇平阳霉素碘化油乳剂是一种对肝细胞、胆道损伤较轻的有效栓塞剂。
Objective:To study the effect of embolization with Ethanol?Pingyangmycin(PYM) and Lipiodol(LIP)emulsion in artery of dog, know damage of liver and bile duct. Materials and Methods:The prole dures of transcatheter intraurterial emblization with Ethanol Pingyangmycin(PYM) and Lipiodol(LIP) emulsion were performed in deffrent artery of twleve health dogs. All cases were diagnosed by funcion of liver and kendy. Rt examintion prior and after the treatment.Finnay, All dogs were killed to study of the liver histology examintion.Result:DSA examintion after the treatment show that artery of the liver all embolizaed.2∶1 bile duct damaged seriouster. 1∶2 cess of the liver damaged seriouser.1∶1 cess of the liver and bile duct damaged relatively lighter funcion of liver damaged temporary.It will be normal in 1～3 weeks after the treatment. Conclusion: Ethanol Pingyangmycin(PYM) and Lipiodol(LIP) emulsion can embolizatoin artery.1∶1Ethanol Pingyangmycin and Lipiodol emulsion is demonstrated as effective method and cell of the liver and bile duct damaged lightlier.
出处
《湖北省卫生职工医学院学报》
2004年第2期15-17,共3页
Journal of Hubei Medical Staff College
