摘要
以水杨酸和乙酸酐为原料,以二氧化硅负载硅钨钼酸H4SiW6Mo6O40/SiO2为催化剂。探讨H4SiW6Mo6O40/SiO2对合成反应的催化活性,系统地研究了水杨酸和乙酸酐的物质的量比、催化剂用量、反应时间等因素对产物收率的影响。实验表明:H4SiW6Mo6O40/SiO2是合成乙酰水杨酸的良好催化剂,固定水杨酸用量为0.015 mol,在n(水杨酸)∶n(乙酸酐)=1∶2.0,催化剂用量为0.3g,反应时间15min的最佳条件下,乙酰水杨酸的收率可达75.1%。
Acetylsalicylic acid was synthesized from salicylic acid and acetic anhydride in the presence of H4 SiW6 Mo6 O4 0/ SiO2 The factors influencing the synthesis were discussed and the best reaction conditions were found out. Experimental results showed that H4 SiW6 Mo6 O4 0/SiO2 is an excellent catalyst. The optimal conditions are: molar ratio of salicylic acid to acetic anhydride is 1:2.0, catalyst dosage is 0.3g(acetylsalicylic acid 0.015 mol) and the reaction time is 15 min, the yield of acetylsalicylic acid can reach 75.1 %.
