摘要
目的探讨食管癌患者治疗前后外周血淋巴细胞的变化及其与预后的关系。方法采用流式细胞术（FCM）检测53例食管癌患者治疗前后外周血淋巴细胞水平。结果食管癌患者治疗后与治疗前比较，CD3+细胞水平升高，差异有显著性，其余指标差异无显著性；Ⅲ～Ⅳ期和Ⅰ～Ⅱ期的患者比较，治疗前CD4+和CD3+细胞水平较低，差异有显著性，其余指标及治疗后各项指标差异均无显著性；有淋巴结转移和无淋巴结转移的患者比较，治疗前自然杀伤细胞（NK）水平较高，差异有显著性，其余指标及治疗后各项指标差异均无显著性；有复发或转移与无复发或转移的患者比较，治疗前CD4+细胞水平较低，CD8+、NK、CD19+细胞水平较高，差异有显著性，治疗后CD4+细胞水平较低，CD8+、NK、CD19+细胞水平较高，差异有显著性，CD3+细胞水平差异无显著性。结论CD4+细胞水平减低伴随CD8+、NK和CD19+细胞水平显著升高，可能是评估食管癌治疗后复发或迅速恶化的标志。
Objective To explore the change of peripheral blood lymphocytes in patients with esophageal cancer before and after the treatment, and its relationship with the prognosis. Methods Flow cytometry (FCM) was used to detect the levels of peripheral blood lymphocytes before and after the treatment in patients with esophageal cancer. Results Compared the patients after treatment with those before treatment, the level of CD3+cells was elevated, the difference was statistically signiifcant, there was no statistically signiifcant difference among the rest of the indicators;Compared the patients with stageⅢ~Ⅳ with those with stageⅠ~Ⅱ, the levels of CD4+and CD3+cells were depressed in patients before treatment, the difference was statistically signiifcant, the rest of the indicators and the difference between each index after treatment had no statistical signiifcance;Compared the patients with lymph node metastasis with those without lymph node metastasis, the level of NK was elevated inpatients before treatment, the difference was statistically signiifcant, the rest of the indicators and the difference between each index after treatment had no statistical signiifcance;Compared the patients with recurrence or metastasis with those without recurrence or metastasis, the level of CD4+cells was depressed in patients before and after the treatment ,and the levels of CD8+, NK cell, CD19+cells levels were elevated, the difference was statistically signiifcant, there was no statistically signiifcant difference of CD3+cells. Conclusion The reducing of CD4+ cells along with the increasing of CD8+ , NK and CD19+ cells may be a sign of assessing recurrence and deteriorating rapidly in patients with esophageal cancer after treatment.
出处
《中国医学前沿杂志（电子版）》
2014年第4期22-25,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
广西科技攻关基金资助项目(桂科攻1355005-3-10)
关键词
食管癌
淋巴细胞
流式细胞术
Esophageal cancer
Lymphocyte
Flow cytometry
