摘要
利用来源于同一猪场的2头猪瘟病毒(HCV)持续感染的带毒母猪及所产35头仔猪(包括13头死胎)和6头阴性对照猪,观察母猪的胎儿发育成活状况、仔猪HCV带毒率及HCV垂直传播对仔猪猪瘟兔化弱毒疫苗(HCLV)免疫效力的干扰作用,同时进行水平传播试验和观察HCV持续感染对母猪繁殖功能的影响。结果表明:HCV持续感染对其中1头母猪的胎儿发育和成活有明显影响,而对另1头母猪的胎儿发育没有明显影响;HCV持续感染母猪可经过胎盘垂直传播病毒给仔猪,传播率达45%～86%;吃初乳和接种HCLV不能阻止带毒仔猪的死亡,9头带毒仔猪在45d内死亡4头;免疫HCLV不能使带毒仔猪产生免疫保护力,5头猪在强毒攻击后死亡4头;HCV垂直传播的带毒猪可发生水平传播,并引起3/4感染猪死亡;HCV持续感染可引起母猪生殖系统病理变化,导致繁殖障碍。
Two sows with field hog cholera virus (HCV) ,thirty-five piglets stem from the two sows and six HCV negative controls were studied. Observation of development of fetuses,survival rate of piglets, HCV vertical transfer rate, and influence of immune protection efficacy of hog cholera lapinization virus (HCLV) in pigs with HCV were carried out in the laboratory. Meanwhile, HCV horizontal transfer between pigs and influence on ability of sows' reproduction by HCV persistent infection were observed.The results indicated: Foetuses' development of one sow was affected obviously by persistent HCV infection. Among fourteen piglets, three were stillbirths, all piglets were weak. Surprisingly, foetuses' development of the other sow was not affected. Sows with persistent infection can transfer HCV to piglets through placenta, vertical transfer rate of one sow was 45%(5/11), the other was 86%(12/14). Mortality of piglets couldn't be blocked by forecolostrum sucking and vaccine vaccination. The HCV infected piglets couldn't produce enough immune protection efficacy by HCLV vaccination. Four of five vaccinated piglets died after challenge of virulent strain of HCV. HCV can spread horizontally by piglets with virus, and made health pig infected, all four HCV antibody negative pigs that feeded in same pen with HCV carring piglets were infected, three of them died; Persistent infection of HCV can lead to disability of reproduction.
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2004年第4期449-453,共5页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然科学基金重大项目(39893290-1-2)
国家"973"项目(G1999011904)
