摘要
结核病是目前世界各国重点防控传染性疾病之一。外泌体(exosomes)是多种细胞分泌的一种含有特异性与非特异性蛋白成分的囊泡结构,是机体免疫细胞之间重要的信息传递介质,其在机体免疫反应中发挥着重要作用。外泌体能呈递表面抗原,激活多种细胞免疫因子,介导巨噬细胞杀伤结核杆菌的细胞免疫反应。外泌体与结核分枝杆菌相互作用研究已经成为当前重大研究热点,有望开发成预防结核病的新型疫苗。
Tuberculosis(TB) is a kind of infectious disease,of which many countries focus on prevention and control at present.Exosome secreted by cells is a kind of vesicle containing the specific and non-specific protein components,which transfer between immune cells and plays a significant role in the immune response.Exosomes can present surface antigen and activate a variety of cellular immune factors for improving macrophage’s capacity of killing Mycobacterium tuberculosis.The interaction between exosomes and Mycobacterium tuberculosis has become a major research interest at present.And new vaccines in this field are developed to prevent tuberculosis.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2013年第2期177-179,共3页
Immunological Journal
基金
国家自然科学基金项目(81071326)
中南大学研究生教育教学改革研究项目(2012jg30)
关键词
外泌体
结核分枝杆菌
巨噬细胞
疫苗
Exosomes
Mycobacterium tuberculosis
Macrophages
Vaccine
