摘要
目的以壳聚糖和海藻酸钠为载体制备雷公藤多苷提取物缓释微球,考察载体材料对雷公藤多苷提取物的载药量、包封率及释放行为的影响。方法采用锐孔凝固浴法制备微球,通过改变壳聚糖浓度、海藻酸钠浓度、氯化钙浓度、海藻酸钠与药物的比例、交联固化时间来考察微球的载药量、包封率和体外释放行为。结果海藻酸钠的浓度、壳聚糖的浓度、氯化钙的浓度及海藻酸钠和壳聚糖的比例对包封率、载药量和体外释放均有一定的影响,而交联固化时间对包封率和载药量有影响,对体外释放影响不明显。结论缓释效果最佳的缓释微球的制备工艺为:壳聚糖、海藻酸钠、氯化钙的质量浓度依次为10、10、30g·L-1,海藻酸钠与药物的质量比为1∶1,预交联时间为30min,继续交联2h。
Objective To prepare Tripterygium wilfordii Hook F sustained-release microspheres using chitosan and alginate as carriers, and to investigate the influence of chitosan and alginate on drug release properties. Methods Microspheres were prepared by piercing-solidifying incubation method. Rotary basket method was used to study the in vitro release. Influence of the ratio of drug to alginate, the concentration of chitosan, alginate and calcium chloride, cross linking time on drug release behavior was investigated, Results The in vitro drug release was affected by the ratio of drug to alginate, the concentration of chitosan, alginate and calcium chloride, the influence of cross linking time was negliable. Conclusions The optimized preparation conditions were as follows: the ratio of alginate to drug was 1:1,the concentration of sodium alginate, calcium chloride and chitosan were 10, 30, 10 g·L-1 respectively, pre-crosslinking time was 30 min, crosslinking solidification time was 2 h.
出处
《中国药剂学杂志（网络版）》
2009年第5期382-390,共9页
Chinese Journal of Pharmaceutics：Online Edition
基金
国家“十一五”科技支撑计划项目(2006BAI09B08-04)
关键词
药剂学
微球
释放度
雷公藤多苷
壳聚糖
海藻酸钠
锐孔凝固浴法
pharmaceutics
microspheres
release degree
Triperygium wilfordii glucosides
chitosan
alginate
piercing-solidfying method
