摘要
目的测定ML120B的细胞膜渗透性。方法采用MDCK-hMDR1单层膜细胞测定ML120B的体外跨膜转运率及转运机制。结果药物的被动转运渗透性为678.9nm·s-1,不加P-糖蛋白(Pgp)抑制剂的外排率Efflux值为0.8,添加Pgp抑制剂的Efflux值为0.5。结论ML120B属于高渗透性药物,并不是Pgp的作用底物。
Objective To determine the passive permeability of ML120B. Methods MDCK-hMDR1 monolayer cells were used to determine the passive permeability of ML120B and its permeation mechanism. Results The passive permeability of ML120B was 678.9 nm·s-1 and the efflux ratio was 0.8 without Pgp inhibitor and 0.5 with Pgp inhibitor. Conclusions ML120B is a highly permeable compound and is not a Pgp substrate.
出处
《中国药剂学杂志（网络版）》
2009年第5期403-408,共6页
Chinese Journal of Pharmaceutics：Online Edition
