摘要
目的:选择适宜的制粒工艺,提高接骨七厘片的片芯质量,利于薄膜包衣进行。方法:采用正交实验,以片芯硬度、脆碎度和外观为考察指标,优选出适宜的粘合剂,以提高接骨七厘片的片芯质量。以保证接骨七厘片的药品质量。结果:以2%聚乙烯吡咯烷酮(PVP)为粘合剂,以75%乙醇为湿润剂,通过高效湿法混合制粒机一步制粒法制粒,可使压制的接骨七厘片的素片外表光洁,硬度达5~6kg·cm2以上,接骨七厘片的素片崩解在20min以内,脆碎度【0.3%。结论:根据接骨七厘片的片芯要求,应用新型粘合剂,能较好地解决老法生产接骨七厘片时的中药麻面、松片、硬度不够的问题,使接骨七厘片达到薄膜包衣的要求。
Objective: The appropriate granulation process is selected, improve the quality of the piece of bone Qili piece of core is proved, which will help the film coating. Methods: The orthogonal test, die hardness, friability, and appearance of the marker, preferably a suitable adhesive are used in order to improve the quality of the piece of bone the Qili piece of core,and ensure the bone Qili piece of the quality of medicines. Results: 2% polyvinylpyrrolidone (PVP) as a binder, 75% ethanol as a wetting agent, and efficient wet mixing granulating machine granulating step granulation, can suppress the bone the Qili piece of plain film appearance of smooth, the hardness of more than 5 ~ 6kg cm2, the bone Qili piece of tablets disintegrating in less than 20min, friability <0.3%. Conclusion: According to core requirements of bone Qili piece, the application of new adhesive can solve the problems: pockmarked face of traditional Chinese medicine, loose piece and softness, and meet the requirements of the coating of bone Qili piece.
出处
《长沙医学院学报》
2012年第1期28-30,共3页
Journal of Changsha Medical University
关键词
接骨七厘片
聚乙烯吡咯烷酮
脆碎度
硬度
崩解度
bone Qili piece
polyvinylpyrrolidone
friability
hardness
disintegration
