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Meta analysis of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia

Meta analysis of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia
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摘要 Objective:To assess the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia.Methods:Related studies of XRCC3 Thr24lMet polymorphism and lung cancer susceptibility of populations in East Asia were collected through searching the Pubmed,Embase Library,SPRINGER.CNKI and CSSCI.Results:According to the entry criteria,there were 8 case-control studies in the assessing system and there were 6 321study cases,including 3 215 patients with lung cancer and 3 106 cases without cancers.Meta analysis results showed the combined OR value of the ratio of genotype Thr/Met+Met/Met and Thr/Thr was 1.03(95%CI:0.89-1.20)(P>0.05).Conclusions:XRCC3 Thr241Met polymorphism may not related to lung cancer susceptibility of populations in East Asia.Allele 241Met did not increase the risk of lung cancer. Objective:To assess the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia.Methods:Related studies of XRCC3 Thr24lMet polymorphism and lung cancer susceptibility of populations in East Asia were collected through searching the Pubmed,Embase Library,SPRINGER.CNKI and CSSCI.Results:According to the entry criteria,there were 8 case-control studies in the assessing system and there were 6 321study cases,including 3 215 patients with lung cancer and 3 106 cases without cancers.Meta analysis results showed the combined OR value of the ratio of genotype Thr/Met+Met/Met and Thr/Thr was 1.03(95%CI:0.89-1.20)(P>0.05).Conclusions:XRCC3 Thr241Met polymorphism may not related to lung cancer susceptibility of populations in East Asia.Allele 241Met did not increase the risk of lung cancer.
作者 Zhi-Song Xing Guang Zhu Yu-Lun Yang Guang-Qiang Feng Guang-Cheng Ding
机构地区 Department of Thoracic Surgery Deportment of Science and Education Department of Radiotherapy
出处 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2014年第6期483-487,共5页 亚太热带医药杂志（英文版）
基金 supported by Medicine Science and Technology Research Project of Hebei Province
关键词 XRCC3 THr241 Met Meta analysis LUNG cancer SUSCEPTIBILITY POPULATIONS in East Asia XRCC3 THr241Met Meta analysis Lung cancer susceptibility Populations in East Asia
分类号 R734.2 [医药卫生—肿瘤]
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参考文献10

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二级参考文献32

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共引文献23

Asian Pacific Journal of Tropical Medicine
2014年 第6期

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