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GRK6 expression in patients with hepatocellular carcinoma 被引量:4

GRK6 expression in patients with hepatocellular carcinoma
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摘要 Objective:To investigate the expression and potential roles of G protein—coupled receptor kinase 6[GRK6]in hepatocellular carcinoma(HCC) patients.Methods:Immunohistochemistry and Western blot was performed to determine GRK6 expression in 73 HCC samples.And the correlation with clinieopathological features was also analyzed.Results:GKK6 expression was significantly higher in HCC than that in normal hepatic tissue.GRK6 was positively correlated with proliferation marker Ki-67,clinical stage,metastasis and survival time.Conclusions: Our results suggested that GUK.6 overexpression plays an important role in HCC.Monitoring the expression of GRK6 maybe helpful in early diagnosis and prognosis of HCC. Objective:To investigate the expression and potential roles of G protein—coupled receptor kinase 6[GRK6]in hepatocellular carcinoma(HCC) patients.Methods:Immunohistochemistry and Western blot was performed to determine GRK6 expression in 73 HCC samples.And the correlation with clinieopathological features was also analyzed.Results:GKK6 expression was significantly higher in HCC than that in normal hepatic tissue.GRK6 was positively correlated with proliferation marker Ki-67,clinical stage,metastasis and survival time.Conclusions: Our results suggested that GUK.6 overexpression plays an important role in HCC.Monitoring the expression of GRK6 maybe helpful in early diagnosis and prognosis of HCC.
作者 Ya-Ping Li
出处 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2013年第3期220-223,共4页 亚太热带医药杂志(英文版)
关键词 HEPATOCELLULAR CARCINOMA GRK6 KI-67 Hepatocellular carcinoma GRK6 Ki-67
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同被引文献15

  • 1W.Michael Korn Division of Gastroenterology and Comprehensive Cancer Canter,University of California San Francisco,San Francisco,CA 94143-0128,USA.Moving toward an understanding of the metastatic process in hepatocellular carcinoma[J].World Journal of Gastroenterology,2001,7(6):777-778. 被引量:13
  • 2Hideki Takami,Mitsuro Kanda,Hisaharu Oya,Soki Hibino,Hiroyuki Sugimoto,Masaya Suenaga,Suguru Yamada,Yoko Nishikawa,Mikako Asai,Tsutomu Fujii,Shuji Nomoto,Yasuhiro Kodera.Evaluation of MAGE‐D4 expression in hepatocellular carcinoma in Japanese patients[J].J Surg Oncol.2013(8)
  • 3Ping Chen,Xia Zhao,Liang Ma.Downregulation of microRNA-100 correlates with tumor progression and poor prognosis in hepatocellular carcinoma[J].Molecular and Cellular Biochemistry (-).2013(1-2)
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