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Serum EGF and NGF levels of patients with brain injury and limb fracture 被引量:21

Serum EGF and NGF levels of patients with brain injury and limb fracture
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摘要 Objective:To explore the expression and significance of human epidermal growth factor(EOF) and nerve growth factor(NGF) in patients with knee osteoarthritis. Methods:RT-PCR and enzyme-linked immunosorbent assay were used to measure the serum EOF and NGF expression levels of patients with limb fracture and brain trauma injurry after 1 d,3 d,7 d,14 d and the relationship between them was analyzed.The level was compared among the simple fracture group,traumatic brain injury group and the normal control group,with 40 cases in each group.Results:The serum NGF levels were significantly different among three groups. Senun NGF,EGF mKNA and protein levels gradually decreased with the increasing injury time in the limb fracture combined with brain injury gnmp,traumatic brain injury group,the simple fracture group and the health control group(P【0.05).Conclusions:The serum of NGF.EGF levels significandy increased when limb fracture combined with brain injury,so EGF and NGF may be involved in the process of fracture healing. Objective:To explore the expression and significance of human epidermal growth factor(EOF) and nerve growth factor(NGF) in patients with knee osteoarthritis. Methods:RT-PCR and enzyme-linked immunosorbent assay were used to measure the serum EOF and NGF expression levels of patients with limb fracture and brain trauma injurry after 1 d,3 d,7 d,14 d and the relationship between them was analyzed.The level was compared among the simple fracture group,traumatic brain injury group and the normal control group,with 40 cases in each group.Results:The serum NGF levels were significantly different among three groups. Senun NGF,EGF mKNA and protein levels gradually decreased with the increasing injury time in the limb fracture combined with brain injury gnmp,traumatic brain injury group,the simple fracture group and the health control group(P<0.05).Conclusions:The serum of NGF.EGF levels significandy increased when limb fracture combined with brain injury,so EGF and NGF may be involved in the process of fracture healing.
出处 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2013年第5期383-386,共4页 亚太热带医药杂志(英文版)
关键词 FRACTURE HEALING TRAUMATIC brain injury EGF NCF Fracture healing Traumatic brain injury EGF NCF
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