期刊文献+

Evaluation of serum and pleural levels of endostatin and vascular epithelial growth factor in lung cancer patients with pleural effusion 被引量:10

Evaluation of serum and pleural levels of endostatin and vascular epithelial growth factor in lung cancer patients with pleural effusion
下载PDF
导出
摘要 Objective:To evaluate the diagnostic value of endostatin(ES),vascular endothelial growth factor (VEGF) and careinoembryonie antigen(CEA) in both serum and pleural effusion of lung cancer patients.Methods:Levels of ES,VEGF and CEA in 52 malignant pleural effusion due to lung cancer and 50 patients with non-malignant disease were measured by using sandwich enzymelinked immunosorbent assay and microparticle enzyme immunoassay.Results:The ES.VEGF and CEA levels in pleural effusion and serum,and their ratio(F/S) were higher in lung cancer group than that in benign group,and the differences were statistically significant(P【0.05).The diagnostic efficiency of ES+VEGF for lung cancer was superior to either single detection.The diagnostic efficiency of ES+VEGK+CEA was superior to either ES+VEGF or ES+CEA.Conclusions: The results suggest that ES,VEGF and CEA might be useful in the differentiation between benign and malignant pleural effusion due to lung cancer.In comparison with either single determination of concentration in serum or pleural fluid,the couiljined detection of two or three markers is of important clinical significance in the diagnosis of lung cancer. Objective:To evaluate the diagnostic value of endostatin(ES),vascular endothelial growth factor (VEGF) and careinoembryonie antigen(CEA) in both serum and pleural effusion of lung cancer patients.Methods:Levels of ES,VEGF and CEA in 52 malignant pleural effusion due to lung cancer and 50 patients with non-malignant disease were measured by using sandwich enzymelinked immunosorbent assay and microparticle enzyme immunoassay.Results:The ES.VEGF and CEA levels in pleural effusion and serum,and their ratio(F/S) were higher in lung cancer group than that in benign group,and the differences were statistically significant(P<0.05).The diagnostic efficiency of ES+VEGF for lung cancer was superior to either single detection.The diagnostic efficiency of ES+VEGK+CEA was superior to either ES+VEGF or ES+CEA.Conclusions: The results suggest that ES,VEGF and CEA might be useful in the differentiation between benign and malignant pleural effusion due to lung cancer.In comparison with either single determination of concentration in serum or pleural fluid,the couiljined detection of two or three markers is of important clinical significance in the diagnosis of lung cancer.
出处 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2012年第3期239-242,共4页 亚太热带医药杂志(英文版)
关键词 PLEURAL EFFUSION SERUM ENDOSTATIN Lung cancer VASCULAR endothelial growth factor Pleural effusion Serum Endostatin Lung cancer Vascular endothelial growth factor
  • 相关文献

参考文献19

  • 1O’Reilly MS,Boehm T,Shing Y,et al.Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor GrowthCell,1997.
  • 2Skovseth D K,Veuger M J,Sorensen D R,et al.Endostatin dramatically inhibits endothelial cell migration vascular morphogenesis,and perivascular cell recruitment in vivo. Blood . 2005
  • 3Suzuki M,Iizasa T,Ko E,et al.Serum endostatin correlates with progression and prognosis of non-small cell lung cancer. Lung Cancer . 2002
  • 4Bremnes R M,Camps C,Sirera R.Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Lung Cancer . 2006
  • 5Sahn SA.Pleural disease related to metastatic maligancies. European Respiratory Journal . 1997
  • 6Rosca EV,Koskimaki JE,Rivera CG,et al.Anti-angio-genic peptides for cancer therapeutics. Curr PharmBiotechnol . 2011
  • 7Koniari I,Koletti B,Apostolakis E.Vascular endothelial growth factor with tumour growth factor-beta,endostatin. proteinases or cytokines might be useful for differential diagnosis of pleural effusions. Interact Cardiovasc Thorac Surg . 2011
  • 8Fiorelli A,Vicidomini G,Di-Domenico M,et al.Vascular endo-thelial growth factor in pleural fluid for differential diagnosis of be-nign and malignant origin and its clinical applications. InteractCardiovasc Thorac Surg . 2011
  • 9Maskell NA,Butland RJ.BTS guidelines for the investigation of a uni- lateral pleural effusion in adults. Thorax . 2003
  • 10Zheng MJ.Endostatin derivative angiogenesis inhibitorsChinese Medical Journal,2009.

同被引文献43

引证文献10

二级引证文献59

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部