摘要
目的探讨异基因外周血造血干细胞移植(ALLO-PBSCT)治疗白血病过程中移植物抗宿主病(GVHD)的发生状况防治方法及疗效。方法Allo-PBSCT治疗白血病21例,预防GVHD发生主要采用环孢霉素A(CsA)加短程甲氨碟呤(MTX)等。结果21例患者经ALLO-PBSCT后均获得造血功能重建,GVHD的发生率为38%,3例重度急性GVHD(aGVHD)死亡2例,GVHD组的复发、死亡率较未出现GVHD组低。结论CsA加短程MTX预防GVHD的发生可获得较好的疗效,GVHD组患者的复发、死亡率低于未出现GVHD组,提示GVHD过程中伴有移植物抗白血病效应(GVL)。
Objective:To determine the incidence and the effective prevention and treatment of graft-versus-host disease(GVHD)for the allogeneic peripheral blood stem cell transplantation(ALLO-PBSCT)for the treatment of leukemia.Methods:21leukemia patients were treated with ALLO-PBSCT,the cyclosporine A(CsA)and short course methotrexate(MTX)were used to prevent GVHD.Results:All patients engrafted were acquired hematopoietic reconstruction,the incidence of GVHD was38%,Ⅲ-ⅣGVHD occurred in3patients and2patients died,the relapse and dead rate was higher in GVHD negative group.Conclusions:To prevent GVHD can acquire more good effective with CsA and short course MTX.The relapse and dead rate of GVHD positive group was lower than GVHD negative group.There was an antileukemia effect of GVHD in the ALLO-PBSCT.
出处
《中国现代医学杂志》
CAS
CSCD
2004年第14期119-121,共3页
China Journal of Modern Medicine
关键词
造血干细胞移植
异基因
白血病
移植物抗宿主病
hematopoietic stem cells transplantation
allogeneic
leukemia
graft-versus-host disease
