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辛伐他汀对中重度慢性心力衰竭患者血脂及血栓事件的影响 被引量:5

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摘要 目的:探讨辛伐他汀对中、重度慢性心力衰竭( CHF)患者血脂及血栓事件的影响。方法选择住院患者222例(心功能Ⅲ~Ⅳ级),随机分为辛伐他汀治疗组(112例),对照组(110例)。所有患者均给予心衰常规治疗,治疗组加辛伐他汀20 mg/d,随访12个月,观察治疗前后血脂的变化及血栓事件的发生。结果治疗组患者总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)较治疗前明显降低(P<0.05)、高密度脂蛋白胆固醇(HDL-C)明显升高(P<0.05),对照组患者血脂无明显改变(P>0.05)。治疗组随访血栓事件发生率为6.3%,显著低于对照组的血栓事件发生率18.2%(P<0.05)。亚组分析结果;冠心病( CAD)心衰治疗组TC、LDL-C的改善均明显优于对照组(P<0.01),血栓事件较对照组下降更显著(P<0.01)。结论中重度CHF患者在拮抗神经-内分泌治疗的基础上,加用辛伐他汀,安全有效,可以进一步改善血脂并降低血栓事件,降低冠心病CHF患者脑卒中发生率。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2014年第9期2325-2327,共3页 Chinese Journal of Gerontology
基金 甘肃卫生行业科研计划项目(No.GSWST2011-23)
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