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^(131)I标记槲皮素治疗失分化及未分化甲状腺癌的可行性 被引量:3

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摘要 甲状腺癌( DTC)是内分泌系统恶性肿瘤,按病理类型可分为乳头状癌( PTC,占70%~75%)、滤泡状癌( FTC,占15%~20%)未分化癌( ATC,占3%~5%)、髓样癌( MTC,占1%~3%)〔1〕。近几十年来,DTC成为了发病率最快的实体肿瘤〔2〕。DTC采取手术治疗+131 I治疗+促甲状腺激素( TSH)治疗是国际公认的治疗三部曲,其预后效果较好,存活率高。131 I是治疗DTC最特异、最有效的放射性药物,可以被甲状腺组织高选择性的吸收,疗效确切。131 I核素治疗的基础是癌灶或转移灶具有摄碘能力,因此对于失分化及ATC患者而言,因肿瘤摄碘能力明显降低或丧失而不适应传统治疗模式,常导致令人遗憾的后果〔3〕。目前,失分化及ATC已跻身于最致命的人类恶性肿瘤之列,如何减少失分化的发生,使其再分化成为临床迫切需要攻克的难题。本文通过分析DTC的相关机制及治疗,并根据先期实验对槲皮素的了解,拟寻找一种新的安全有效的靶向药物,以期达到提高DTC内放疗的疗效,减少失分化的发生,且达到对失分化及未分化的DTC行再分化治疗的目的。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2014年第9期2592-2594,共3页 Chinese Journal of Gerontology
基金 国家自然科学基金资助项目(No.81271526)
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  • 1金念祖,茅力,朱燕萍,赵人琤,赵鸿雁,余静,陈景衡,方泰惠.槲皮素对人肺癌细胞和小鼠Lewis肺癌移植瘤细胞增殖的抑制作用及机制探讨[J].医学研究生学报,2005,18(2):125-128. 被引量:13
  • 2于利人,张东昌,王瑞珉,靳秋月,陈立军.槲皮素诱导K562细胞凋亡机制探讨[J].中国肿瘤临床,2005,32(9):505-507. 被引量:11
  • 3苑辉卿,杨玲玲,姜安丽,孔峰,张建业,Charles YF YOUNG.槲皮素对前列腺癌细胞增殖及转录因子Sp1功能的抑制作用[J].中国生物化学与分子生物学报,2005,21(5):673-678. 被引量:21
  • 4苑辉卿,郭怀芳,贺美兰,孔峰,胡晓燕,姜安丽,徐霞,张建业,Charles YF Young.c-Jun和CBP在槲皮素抑制前列腺癌中的作用[J].药学学报,2006,41(9):819-824. 被引量:10
  • 5Aghdassi A, Phillips P, Dudeja V, et al. Heat Shock Protein 70 Increases Tumorigenicity and Inhibits Apoptosis in Pancreatic Adenocarcinoma [J]. Cancer Res, 2007,67 (2) : 616-625.
  • 6Brisdelli F, Coccia C, Cinque B, et al. Induction of apoptosis by quercetin: different response of human chronic myeloid ( K562 ) and acute lymphoblastic (HSB-2)leukemia cells [J]. Mol Cell Biochemist, 2007,296( 1- 2) : 137-149.
  • 7Choi E J, Bae S M, Ahn W S. Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells [J]. Arch Pharm Res, 2008,31 (10) : 1281-1285.
  • 8Luo H, Jiang B H, King S M, et al. Inhibition of cell growth and VEGF expression in ovarian cancer cells by flavonoids [J]. Nutri Can, 2008,60 (6) : 800-809.
  • 9Kamaraj S, Vinodhkumer R, Nandakumar, et al. The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo (a)pyrene [J]. Biol Pharm Bull, 2007,30 (12) : 2268-2273.
  • 10Shen J, Zhang W, Wu J, et al. The synergistic reversal effect of muhidrug resistance by quercetin and hyperthermia in doxorubicin-resistant human myelogenous leukemia cells [J]. Inter J Hyperthe rmia, 2008,24(2): 151-159.

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  • 1孙占勇,程若川.甲状腺乳头状癌的发病特点及诊治现状[J].昆明医科大学学报,2012,33(S1):113-115. 被引量:5
  • 2彭韦霞,文芳.PPAR-γ在甲状腺癌中的研究[J].医学综述,2006,12(20):1240-1242. 被引量:1
  • 3吴敏华,陈亚男,刘艳清.周维顺主任医师治疗甲状腺癌经验[J].河南中医,2007,27(2):22-22. 被引量:16
  • 4Armaghan Fard-Esfahani,Alireza Emami-Ardekani,Babak Fallahi,Pezhman Fard-Esfahani,Davood Beiki,Arman Hassanzadeh-Rad,Mohammad Eftekhari.Adverse effects of radioactive iodine-131 treatment for differentiated thyroid carcinoma[J]. Nuclear Medicine Communications . 2014 (8)
  • 5Ji In Lee,Yun Jae Chung,Bo Youn Cho,SeMin Chong,Ju Won Seok,Sung Jun Park.Postoperative-stimulated serum thyroglobulin measured at the time of 131 I ablation is useful for the prediction of disease status in patients with differentiated thyroid carcinoma[J]. Surgery . 2013 (6)
  • 6Giuseppe Barbesino,Melanie Goldfarb,Sareh Parangi,Jingyun Yang,Douglas S Ross,Gilbert H Daniels.Thyroid Lobe Ablation with Radioactive Iodine as an Alternative to Completion Thyroidectomy After Hemithyroidectomy in Patients with Follicular Thyroid Carcinoma: Long-Term Follow-Up. Thyroid . 2012
  • 7B Vrndic Olgica,M Milo?evic-Djordjevic Olivera,C Mijatovic Teodorovic Ljiljana,Z Jeremic Marija,M Sto?ic Ivana,V Grujicic Darko,T Zivancevic Simonovic Snezana.Correlation between Micronuclei Frequency in Peripheral Blood Lymphocytes and Retention of 131-I in Thyroid Cancer Patients. The Tohoku journal of experimental medicine . 2013
  • 8Saengsuda Y.Radioiodine remnant ablation in low-risk differentiated thyroid cancer. Journal of the Medical Association of Thailand . 2013
  • 9张王峰,袁梦晖,蒋仁晶,徐文斌,卢受强.放射性^(131)碘治疗对甲状腺癌患者白细胞的影响[J].现代肿瘤医学,2010,18(5):877-880. 被引量:12
  • 10王斌,林兰,倪青,苏诚炼.中医辅助西医治疗甲状腺癌优势探究[J].北京中医药,2011,30(5):354-356. 被引量:31

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