摘要
虽然手术仍是目前唯一有可能治愈结直肠癌肝转移的手段,但是在结直肠癌肝转移的诊疗方面发展迅速。多学科团队综合治疗和分组治疗逐渐成为诊疗规范。对可切除的结直肠癌肝转移患者,在围手术期也应实施标准化疗,是否加用靶向药物尚无定论。实施转化性化疗时应选择高效化疗方案,并尽量缩短疗程,且一旦转移灶转化为可切除,就应积极安排手术。肝转移灶不可切除的患者,是否切除原发灶也存在争议。在肝转移灶局部治疗方面的新技术发展迅速,可改善患者生存。
Although surgery is the only potentially curative method for colorectal liver metastases (CRLM),there are many advances in the treatments of CRLM .Multidisciplinary team and group therapy have become the standard treatments of CRLM .For patients with resectable CRLM , perioperative standard chemotherapy is necessary .However , whether the targeted therapy is needed to combined with is still inconclusive .Efficient chemotherapy regimen with short courses should be chosen for convertible therapy .And these patients should be operated as soon as the metastases become resectable .Resection of the primary tumor remains controversial in asymptomatic patients with unresectable CRLM .Some new locoregional therapies are developing fast to improve the survival .
出处
《中华结直肠疾病电子杂志》
2014年第1期5-8,共4页
Chinese Journal of Colorectal Diseases(Electronic Edition)
基金
国家自然科学基金项目(81272390)
上海市卫生系统优秀学科带头人项目(XBR2011031)
上海市科技人才计划项目(12XD1401900)
关键词
结直肠癌肝转移
多学科团队
围手术期化疗
转化性治疗
局部治疗
Colorectal liver metastases
Multidisciplinary team
Perioperative chemotherapy
Convertible therapy
Locoregional therapy
