摘要
目的探讨USP22及其可能靶点在大肠癌组织中的表达及意义。方法应用RTPCR方法检测82例大肠癌组织中USP22及其可能靶点的mRNA表达情况。结果 USP22 mRNA的表达与BMI-1 mRNA(r=0.790,P<0.0001),c-Myc mRNA(r=0.528,P<0.0001)、cyclin D2 mRNA(r=0.657,P<0.0001),但是与p16INK4a mRNA(r=0.103,P=0.358)和p14ARF mRNA(r=0.039,P=0.731)无关。结论 USP22可能是通过不依赖INK4a/ARF的方式,而通过调节Akt的活性来控制细胞周期的进展。
Objective To investigate the expression of USP 22 and its potential targets in colorectal carcinoma.Methods 82 cases of colorectal carcinoma were examined by quantitative RT-PCR.Results Statistical correlation analysis in mRNA level shown that USP 22 was strongly correlated with BMI-1 ( r =0.790,P<0.0001),c-Myc(r =0.528,P <0.0001) and cyclin D2(r =0.657,P <0.0001),but not correlated with p16INK4a(r=0.103,P =0.358)or p14ARF(r =-0.039,P =0.731).Conclusion USP22 may activate BMI1 oncogene-driven pathway signature such as INK4a/ARF or Akt signature via activating the c-Myc-targeted genes such as cyclinD 2,which may act as important role in tumor progression .
出处
《中华结直肠疾病电子杂志》
2014年第1期22-24,共3页
Chinese Journal of Colorectal Diseases(Electronic Edition)
基金
高等学校博士学科点专项科研基金(20102307110011)
