摘要
核酸适配子是通过指数富集的配体系统进化(systematic evolution of ligands by exponential enrichment,SELEX)技术从单链随机寡核苷酸文库中筛选得到的单链寡核苷酸配体,其与靶标的结合具有高特异性及高亲和力等优点,使其能广泛地应用于疾病诊断研究。适配子在生化检测、新肿瘤标志物发现、分子成像、病原微生物检测等领域的研究应用中均有报道,并显示出良好的应用前景。
Aptamers are single-stranded oligonucleotide ligands selected from a random pool of oligonucleotide sequences by systematic evolution of ligands by exponential enrichment. With the advantages of binding to targets with high specii city and ai nity, aptamers have been used in the diagnosis widely, such as biochemistry detection, discovery of new tumor markers, molecular imaging, pathogenic and microorganism detection, showing a good application prospect.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2014年第3期320-324,共5页
Journal of Central South University ：Medical Science
基金
江西省科技支撑计划项目(20133BBG70025)
江西省教育厅科技落地计划项目(KJLD13014)~~
关键词
适配子
指数富集的配体系统进化
靶标
诊断
aptamer
systematic evolution of ligand by exponential enrichment
target
diagnosis
