摘要
以聚乙二醇6000和泊洛沙姆188(PEG6000∶P188=1∶2)为联合载体,通过熔融法制备阿苯达唑固体分散体。当阿苯达唑与联合载体的比例为1∶5时,通过相溶解度试验和体外溶出度的测定,评价该固体分散体的溶出特性。通过X-射线衍射法、红外光谱法及扫描电镜方法对固体分散体进行物相鉴定。结果表明,PEG6000和P188作为联合载体制备阿苯达唑固体分散体时,能显著提高阿苯达唑的体外溶出度,达90.48%。物相鉴定显示,联合载体和药物之间未发生化学反应,固体分散体以非晶型态存在。综上,选出PEG6000和P188比例为1∶2作为联合载体,利用熔融法制备固体分散体能显著提高阿苯达唑的体外溶出度,且制备方法简单。
Solid dispersions of albendazole were prepared by melt technique using polyethylene glycol 6000(PEG6000)and poloxamer 188(P188)in combination(1∶2).When the ratio of albendazole(ABZ)and combined carrier was 1∶5,the dissolution characteristics of solid dispersion were evaluated through measuring the phase solubility studies and dissolution studies.The solid dispersion was investigated using X-ray diffraction analysis,Fourier-transform infrared spectroscopy and scanning electron microscopy.The results showed that PEG6000and P188were recognised as a better combined carrier when preparing solid dispersion of albendazole,and can significantly improve the in vitro dissolution rate to 90.48%.No chemical interaction was found between ABZ and combined carrier,and solid dispersion pattern is amorphous shape.These results indicated that as a combined carrier,the proper ratio of elected PEG6000to P188was 1to 2,and preparation by melt technique for solid dispersion can significantly improve the dissolution of ABZ,and the preparation is simple.
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2014年第6期1018-1023,共6页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
东北农业大学动物普通疾病防治重点实验室(120105)
关键词
阿苯达唑
固体分散体
溶出度
联合载体
albendazole
solid dispersion
dissolution
combined carried
