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别嘌醇治疗慢性肾衰竭合并高尿酸血症患者的疗效及对UA、Cr、BUN水平的影响 被引量:10

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摘要 目的研究别嘌醇治疗慢性肾衰竭合并高尿酸血症(CFCH)患者的疗效及对UA、Cr、BUN水平的影响。方法 2012年2月至2013年3月,70例CFCH患者以数字法随机分成观察组(35例)和对照组(35例)。对照组实施低盐以及低蛋白饮食,并予以常规药物治疗。观察组在此基础上另给予别嘌醇治疗。对比两组治疗前后血生化指标、血压以及UA、Cr、BUN水平变化情况。结果观察组与对照组Hb、ALB、GHbAlc以及血脂和血压水平差异均无统计学意义(均P>0.05)。观察组治疗后UA水平为(329.87±38.17)μmol/L,Cr水平为(303.18±139.68)μmol/L,BUN水平为(18.41±3.51)mmol/L,均显著低于对照组治疗后的(513.57±65.75)μmol/L,(401.01±182.70)μmol/L,(23.17±6.13)mmol/L。观察组治疗后UA水平亦显著低于治疗前的(511.49±60.32)μmol/L;Cr水平和BUN水平均显著高于治疗前的(217.73±83.61)μmol/L,(14.06±4.07)mmol/L(均P<0.05)。结论别嘌醇药物治疗CFCH病患,可通过降低UA水平,缓解Cr和BUN水平,使慢性肾衰竭进展得以控制,效果明显。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2014年第7期1848-1849,共2页 Chinese Journal of Gerontology
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