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肝细胞肝癌中SALL4蛋白表达及其临床病理意义 被引量:4

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摘要 目的探讨婆罗双树样基因4(SALL4)在肝细胞癌(HCC)发生和进展中的作用。方法应用蛋白免疫印迹方法检测30例HCC患者手术切除的癌组织和癌旁组织中SALL4蛋白表达情况。结果 90%肝癌组织中SALL4的蛋白表达显著高于癌旁组织;肝癌组织中SALL4蛋白表达水平与性别、年龄、肿瘤大小、乙肝、病理分级、肿瘤包膜和门脉癌栓差异均无显著性,而与甲胎蛋白(AFP)有关。结论 SALL4蛋白高表达可能增加肝癌细胞的增殖,促进肝癌的进展。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2014年第10期2714-2715,共2页 Chinese Journal of Gerontology
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参考文献5

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同被引文献33

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  • 8吕强声,武寿荣,吴玮,陆园园,顾文静,姚登福.肝癌特异性AFP及端粒酶活性联合分析对肝癌的诊断价值[J].天津医药,2008,36(11):846-849. 被引量:5
  • 9苏宁,郑大勇,陈斌,申鹏,罗荣城.应用组织芯片技术检测GPC3蛋白在肝细胞癌及其他肿瘤中的表达[J].广东医学,2009,30(9):1312-1314. 被引量:3
  • 10熊利华,陈春琴,张春峰,方叶青.血清α-L-岩藻糖苷酶与甲胎蛋白和糖类抗原19-9在原发性肝癌诊断中的作用[J].临床和实验医学杂志,2010,9(4):263-264. 被引量:9

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