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重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白联合甲氨蝶呤治疗早期类风湿关节炎临床疗效观察 被引量：2

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摘要 类风湿关节炎(rheumatoid arthritis;RA)是一种慢性进行性、以累及周围小关节为主的多系统性炎症性自身免疫病,其特征性症状为对称性、周围性多关节慢性炎性病变。临床表现为受累关节疼痛,肿胀,功能下降,病变呈持续、反复发作过程。RA具有较高的致残率,所以早期诊断、早期治疗对RA病人具有重要意义。
作者 王勇 李鸿斌 肖镇
机构地区 内蒙古医学院附属医院风湿科
出处 《内蒙古医科大学学报》 2012年第S2期111-113,共3页 Journal of Inner Mongolia Medical University
基金 内蒙古自治区自然科学基金(2009MS1131) 内蒙古医学院青年基金(NY2008QN015)
关键词 类风湿关节炎 重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白 甲氨蝶呤
分类号 R [医药卫生]
  • 相关文献

参考文献8

  • 1胡大伟,鲍春德,陈顺乐,古洁若,栗占国,孙凌云,韩星海,倪立青.重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白治疗类风湿关节炎双盲随机多中心对照临床研究[J].中华风湿病学杂志,2005,9(11):664-668. 被引量：86
  • 2Kameda H,Kanbe K,Sato E,et al.Continuation of Methotrexate Resulted in Better Clinical and Radiographic Outcomes Than Discontinuation upon Starting Etanercept in Patients with Rheumatoid Arthritis:52-week Results from the JESMR Study. The Journal of Rheumatology . 2011
  • 3Emery P,Breedveld FC,Hall S,et al.Comparison of methotrexate monotherapy with a combination of methotrexate and etenercept in active,early,moderate to severe rheumatoid arthritis (COMET) a randomized,double-blind,parallel treatment trial. The Lancet . 2008
  • 4J Huang,N Stewart,J Crabbe.A 1-year follow-up study of dynamic magnetic resonance imaging in early rheumatoid arthritis reveals synovitis to be increased in shared epitope-positive patients and predictive of erosions at 1?year. Rheumatology . 2000
  • 5Comby,E,Tanaff,P,Mariotte,D,Costentin-Pignol,V,Marcelli,C,Ballet,JJ.Evolution of antinuclear antibodies and clinical patterns in patients with active rheumatoid arthritis with long term infliximab therapy. The Journal of Rheumatology . 2006
  • 6Atzeni F,Tufiel M,Capsoni F,et al.Autoimmunity andanti TNF alpha agents. Annals of the New York Academy of Sciences . 2005
  • 7D Heijde,L Klareskog,R Landewé,GA Bruyn,A Cantagrel,P Durez.Disease remission and sustained halting of radiographic progression with combination etanercept and methotrexate in patients with rheumatoid arthritis. Arthritis and Rheumatism . 2007
  • 8van der Heijde D,Klareskog L,Rodriguez-Valverde V,et al.Comparison of etanercept and methotrexate,alone and combined, in the treatment of rheumatoid arthritis:two-year clinical and radiograhpic results from the TEMPO study,a double-blind,randomized trial. Arthritis and Rheumatism . 2006

二级参考文献12

  • 1Feldmann M, Brennan FM, Maini RN. The role of cytokines in rheumatoid arthritis. Ann Rev Immunol, 1996, 14: 397-440.
  • 2Wooley PH, Dutcher J, Widmer MB, et al. Influence of a recombinant human soluble tumor necrosis factor receptor FC fusion protein on type Ⅱ collagen-induced arthritis in mice. J Immunol,1993, 151: 6602-6607.
  • 3Felson DT, Anderson JJ, Boers M, et al. American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum, 1995, 6: 727-735.
  • 4Felson DT, Anderson JJ, Boers M, et al. Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum, 1995, 38:727-735.
  • 5American College of Rheumatology Ad Hoc Committee on Clinical Guidelines. Guidelines for the management of rheumatoid arthritis. Arthritis Rheum, 1996, 39: 713.
  • 6Cash JM, Klippel JH. Second-line drug therapy for rheumatoid arthritis. New Engl J Med, 1994, 330: 1369-1375.
  • 7Firestein GS, Zvaifler NJ. Anticytokine therapy in rheumatoid arthritis. New Engl J Med, 1997, 337: 195-197.
  • 8Bathon JM, Martin RW, Fleischmann RM, et al. A comparison of Etanercept and methotrexate in patients with early rheumatoid arthritis. New Eng J Med, 2000, 343: 1586-1593.
  • 9Moreland LW, Cohen SB, Baumgartner SW, et al. Long-term safety and efficacy of etanercept in patients with rheumatoid arthritis. J Rheumatol,2001, 28: 1238-1244.
  • 10Weinblatt ME, Kremer JM, Bankhurst A, et al. A trial of etanercept: a recombinant tumor necrosis factor receptor: Fc fusion protein in patients with rheumatoid arthritis receiving methotrexate.New Engl J Med, 1999, 340: 253-259.

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内蒙古医科大学学报
2012年 第S2期

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