摘要
目的研究死亡相关蛋白激酶(death associated protein kinase,DAPK)在原发性肝细胞癌(HCC)组织中的表达及其与HCC临床病理特征的关系。方法应用免疫组织化学SP法检测DAPK在50例HCC组织及其癌旁组织和5例正常肝脏组织中的表达。结果 DAPK在HCC组织中的阳性率为36%,明显低于癌旁组织62%及正常肝组织100%(P<0.05);DAPK低表达与HCC组织分化程度、淋巴结转移有关(P<0.05)。结论 DAPK表达下调在HCC的发生发展中可能起重要作用。
Objective To investigate the expression of death associated protein kinase(DAPK) in hepatocellular carcinoma(HCC) and its correlation with clinicopathological characteristic.Methods SP immunohistochemistry method was applied to detect the expression of DAPK in 50 surgical liver tissue samples and its paracarcinoma tissue samples and 5 normal liver tissue samples.Results The expression of DAPK in HCC tissue,paracarcinoma tissue and normal liver tissue were 36%,62% and 100%,respectively.The positive rate of DAPK was significantly lower than that of paracarcinoma tissue and normal liver tissue.The decreased expression of DAPK was correlated with HCC differentiation degree and lymph node metastasis(P < 0.05) in HCC.Conclusions The decreased expression of DAPK may play an important role in hepatocarcinogenesis.
出处
《中国肝脏病杂志（电子版）》
CAS
2009年第2期9-13,共5页
Chinese Journal of Liver Diseases：Electronic Version
