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白细胞介素-6促进肿瘤骨转移的作用机制 被引量:2

The Mechanism of Interleukin-6 in Cancer Bone Metastasis
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摘要 骨是恶性肿瘤最常见的转移部位之一。白细胞介素-6(Interleukin-6,IL-6)作为一种多功能细胞因子,除了作用于成骨细胞和破骨细胞调控骨代谢外,在骨微环境中以自分泌和旁分泌作用方式通过激活胞内多种信号转导途径促进肿瘤细胞增殖和生长,同时增强肿瘤细胞的多药耐受。IL-6可能作为一个重要的肿瘤治疗靶点在肿瘤治疗中发挥重要作用。 骨是恶性肿瘤最常见的转移部位之一。白细胞介素-6(Interleukin-6,IL-6)作为一种多功能细胞因子,除了作用于成骨细胞和破骨细胞调控骨代谢外,在骨微环境中以自分泌和旁分泌作用方式通过激活胞内多种信号转导途径促进肿瘤细胞增殖和生长,同时增强肿瘤细胞的多药耐受。IL-6可能作为一个重要的肿瘤治疗靶点在肿瘤治疗中发挥重要作用。
作者 杨德猛 王捷
出处 《现代生物医学进展》 CAS 2011年第S1期4787-4789,共3页 Progress in Modern Biomedicine
关键词 肿瘤 白细胞介素-6 骨代谢 信号转导途径 Tumors Interleukin-6 Bone metabolism Signaling transduction pathways
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