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Olfactory receptor gene family evolution in stickleback and medaka fishes 被引量:3

Olfactory receptor gene family evolution in stickleback and medaka fishes
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摘要 Interaction of olfactory receptor (OR) genes with environmental odors is regarded as the first step of olfaction.In this study,OR genes of two fish,medaka (Oryzias latipes) and stickleback (Gasterosteus aculeatus),were identified and an evolutional analysis was conducted.The selection pressure of different TM regions and complete coding region were compared.Three TM regions (TM4,TM5 and TM6) were found to have higher average Ka/Ks values,which might be partly caused by positive selection as suggested by subsequent positive selection analysis.Further analysis showed that many PTSs overlap,or are adjacent to previously deduced binding sites in mammals.These results support the hypothesis that binding sites of fish OR genes may evolved under positive selection. Interaction of olfactory receptor (OR) genes with environmental odors is regarded as the first step of olfaction.In this study,OR genes of two fish,medaka (Oryzias latipes) and stickleback (Gasterosteus aculeatus),were identified and an evolutional analysis was conducted.The selection pressure of different TM regions and complete coding region were compared.Three TM regions (TM4,TM5 and TM6) were found to have higher average Ka/Ks values,which might be partly caused by positive selection as suggested by subsequent positive selection analysis.Further analysis showed that many PTSs overlap,or are adjacent to previously deduced binding sites in mammals.These results support the hypothesis that binding sites of fish OR genes may evolved under positive selection.
出处 《Science China(Life Sciences)》 SCIE CAS 2010年第2期257-266,共10页 中国科学(生命科学英文版)
基金 supported by grants from National Natural Science Foundation of China (Grant Nos. 30600062 and 30530120)
关键词 OLFACTORY RECEPTOR POSITIVE selection BINDING SITE olfactory receptor positive selection binding site
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