期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Computational RNomics:Structure identification and functional prediction of non-coding RNAs in silico 被引量：7

Computational RNomics:Structure identification and functional prediction of non-coding RNAs in silico
原文传递
导出
摘要 The eukaryotic genome contains varying numbers of non-coding RNA(ncRNA) genes."Computational RNomics" takes a multidisciplinary approach,like information science,to resolve the structure and function of ncRNAs.Here,we review the main issues in "Computational RNomics" of data storage and management,ncRNA gene identification and characterization,ncRNA target identification and functional prediction,and we summarize the main methods and current content of "computational RNomics". The eukaryotic genome contains varying numbers of non-coding RNA(ncRNA) genes."Computational RNomics" takes a multidisciplinary approach,like information science,to resolve the structure and function of ncRNAs.Here,we review the main issues in "Computational RNomics" of data storage and management,ncRNA gene identification and characterization,ncRNA target identification and functional prediction,and we summarize the main methods and current content of "computational RNomics".
作者 ZHENG LingLing & QU LiangHu Key Laboratory of Gene Engineering of the Ministry of Education,State Key Laboratory for Biocontrol,Sun Yat-sen University,Guangzhou 510275,China
出处 《Science China(Life Sciences)》 SCIE CAS 2010年第5期548-562,共15页 中国科学（生命科学英文版）
基金 supported by the National Natural Science Foundation of China (Grant Nos. 30830066 and 30771151) the National Basic Research Program (Grant No. 2005CB724600)
关键词 NON-CODING RNA EUKARYOTE COMPUTATIONAL RNomics non-coding RNA eukaryote computational RNomics
分类号 Q522 [生物学—生物化学]
  • 相关文献

参考文献86

  • 1XIA Wei, CAO GuoJun & SHAO NingSheng· Beijing Institute of Basic Medical Sciences, Beijing 100850.Progress in miRNA target prediction and identification[J].Science China(Life Sciences),2009,52(12):1123-1130. 被引量：14
  • 2Liang-Hu Qu College of Life Sciences,Sun Yan-Sen University,Guangzhou 510275,China.RNomics:The New Frontier in the post-genomic era[J].Science China(Life Sciences),2009,52(3):193-194. 被引量：6
  • 3Liu C,,Bai B,Skogerbo G,et al.NONCODE:An integrated knowledge database of non-coding RNAs. Nucleic Acids Research . 2005
  • 4Gardner P P,Daub J,Tate J G,et al.Rfam: Updates to the RNA families database. Nucleic Acids Research . 2009
  • 5Kin T,Yamada K,Terai G,et al.fRNAdb: A platform for mining/annotating functional RNA candidates from non-coding RNA sequences. Nucleic Acids Research . 2007
  • 6Lestrade L,Weber M J.snoRNA-LBME-db,a comprehensive database of human H/ACA and C/D box snoRNAs. Nucleic Acids Research . 2006
  • 7Yang J,Shao P,Zhou H,et al.deepBase:A database for deeply annotating and mining deep sequencing data. Nucleic Acids Research . 2010
  • 8Lall S,Grün D,Krek A,et al.A genome-wide map of conserved microRNA targets in C.elegans. Current Biology . 2006
  • 9Maragkakis M,,Reczko M,Simossis V A,et al.DIANA-microT web server: Elucidating microRNA functions through target prediction. Nucleic Acids Research . 2009
  • 10Selbach M,Schwanh-usser B,Thierfelder N,et al.Widespread changes in protein synthesis induced by microRNAs. Nature . 2008

二级参考文献39

  • 1Lagos-Quintana M,Rauhut R,Lendeckel W,et al.Identification of novel genes coding for small expressed RNAs. Science .
  • 2Bartel D P.microRNAs:Genomics,biogenesis,mechanism,and function. Cell .
  • 3Hwang H W,Mendel J T.microRNAs in cell proliferation,cell death,and tumorigenesis. British Journal of Cancer . 2006
  • 4Zhang Y.miRU:An automated plant miRNA target prediction server. Nucleic Acids Research . 2005
  • 5Andrew G,Kyle K F,Wendy K J.microRNA targeting specificity in mammals:determinants beyond seed pairing. Molecular Cell . 2007
  • 6Kruger J,Rehmsmeier M.RNAhybrid:microRNA target prediction easy,fast and flexible. Nucleic Acids Research . 2006
  • 7Bartel B,Bartel DP.MicroRNAs: at the root of plant development. Plant Physiology . 2003
  • 8Lim L P,Glasner M E,Yekta S,et al.Vertebrate microRNA genes. Science . 2003
  • 9Lee RC,Feinbaum RL,Ambros V.The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell . 1993
  • 10Cheng AM,Byrom MW,Shelton J,et al.Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Research . 2005

共引文献17

同被引文献203

引证文献7

二级引证文献29

Science China(Life Sciences)
2010年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部