期刊文献+

Gastroesophageal reflux disease:From pathophysiology to treatment 被引量:19

Gastroesophageal reflux disease:From pathophysiology to treatment
下载PDF
导出
摘要 This review focuses on the pathophysiology of gastroesophageal reflux disease (GERD) and its implications for treatment. The role of the natural anti-reflux mechanism (lower esophageal sphincter, esophageal peristalsis, diaphragm, and trans-diaphragmatic pressure gradient), mucosal damage, type of refluxate, presence and size of hiatal hernia, Helicobacter pylori infection, and Barrett’s esophagus are reviewed. The conclusions drawn from this review are: (1) the pathophysiology of GERD is multifactorial; (2) because of the pathophysiology of the disease, surgical therapy for GERD is the most appropriate treatment; and (3) the genesis of esophageal adenocarcinoma is associated with GERD. This review focuses on the pathophysiology of gastroesophageal reflux disease (GERD) and its implications for treatment. The role of the natural anti-reflux mechanism (lower esophageal sphincter, esophageal peristalsis, diaphragm, and trans-diaphragmatic pressure gradient), mucosal damage, type of refluxate, presence and size of hiatal hernia, Helicobacter pylori infection, and Barrett’s esophagus are reviewed. The conclusions drawn from this review are: (1) the pathophysiology of GERD is multifactorial; (2) because of the pathophysiology of the disease, surgical therapy for GERD is the most appropriate treatment; and (3) the genesis of esophageal adenocarcinoma is associated with GERD.
机构地区 Department of Surgery
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第30期3745-3749,共5页 世界胃肠病学杂志(英文版)
关键词 GASTROESOPHAGEAL REFLUX disease PATHOPHYSIOLOGY Acid REFLUX Non-acid REFLUX ESOPHAGEAL MANOMETRY AMBULATORY pH Barrett’s esophagus ESOPHAGEAL adenocarcinoma Gastroesophageal reflux disease Pathophysiology Acid reflux Non-acid reflux Esophageal manometry Ambulatory pH Barrett’s esophagus Esophageal adenocarcinoma
  • 相关文献

参考文献52

  • 1Jeffrey H. Peters,N. Avisar.The Molecular Pathogenesis of Barrett’s Esophagus: Common Signaling Pathways in Embryogenesis Metaplasia and Neoplasia[J]. Journal of Gastrointestinal Surgery . 2010 (1)
  • 2Philip O. Katz,Stacey Zavala.Proton Pump Inhibitors in the Management of GERD[J]. Journal of Gastrointestinal Surgery . 2010 (1)
  • 3Piero M. Fisichella,Marco G. Patti.Gastroesophageal Reflux Disease and Morbid Obesity: Is There a Relation?[J]. World Journal of Surgery . 2009 (10)
  • 4Marco G. Patti,Warren J. Gasper,Piero M. Fisichella,Ian Nipomnick,Francesco Palazzo.Gastroesophageal Reflux Disease and Connective Tissue Disorders: Pathophysiology and Implications for Treatment[J]. Journal of Gastrointestinal Surgery . 2008 (11)
  • 5Mohamed Merrouche,Jean-Marc Sabaté,Pauline Jouet,Florence Harnois,Stefano Scaringi,Benoit Coffin,Simon Msika.Gastro-Esophageal Reflux and Esophageal Motility Disorders in Morbidly Obese Patients before and after Bariatric Surgery[J]. Obesity Surgery . 2007 (7)
  • 6Fernando A. M. Herbella,Matthew P. Sweet,Pietro Tedesco,Ian Nipomnick,Marco G. Patti.Gastroesophageal Reflux Disease and Obesity. Pathophysiology and Implications for Treatment[J]. Journal of Gastrointestinal Surgery . 2007 (3)
  • 7F. A. M. Herbella,P. Tedesco,I. Nipomnick,P. M. Fisichella,M. G. Patti.Effect of partial and total laparoscopic fundoplication on esophageal body motility[J]. Surgical Endoscopy . 2007 (2)
  • 8E. Quiroga,F. Cuenca-Abente,D. Flum,E. P. Dellinger,B. K. Oelschlager.Impaired esophageal function in morbidly obese patients with gastroesophageal reflux disease: evaluation with multichannel intraluminal impedance[J]. Surgical Endoscopy . 2006 (5)
  • 9B. Dallemagne,J. Weerts,S. Markiewicz,J.-M. Dewandre,C. Wahlen,B. Monami,C. Jehaes.Clinical results of laparoscopic fundoplication at ten years after surgery[J]. Surgical Endoscopy . 2006 (1)
  • 10Adam T. Meneghetti M.D.,Pietro Tedesco M.D.,Tanuja Damani M.D.,Marco G. Patti M.D..Esophageal mucosal damage may promote dysmotility and worsen esophageal acid exposure[J]. Journal of Gastrointestinal Surgery . 2005 (9)

同被引文献183

引证文献19

二级引证文献80

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部