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Effect of medical and surgical treatment of Barrett's metaplasia 被引量:2

Effect of medical and surgical treatment of Barrett’s metaplasia
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摘要 Barrett’s esophagus (BE) is a change in the esophageal mucosa as a result of long-standing gastroesophageal reflux disease. The importance of BE is that it is the main risk factor for the development of esophageal adenocarcinoma, whose incidence is currently growing faster than any other cancer in the Western world. The aim of this review was to compare the common treatment modalities of BE, with the focus on proton pump inhibitors and operative fundoplication. We performed a literature search on medical and surgical treatment of BE to determine eligible studies for this review. Studies on medical and surgical treatment of BE are discussed with regard to treatment effect on progression and regression of disease. Although there is some evidence for control of reflux with either medical or surgical therapy, there is no def initive evidence that either treatment modality decreases the risk of progression to dysplasia or cancer. Even though there is a trend toward antireflux surgery being superior, there are no def initive studies to prove this. Barrett’s esophagus (BE) is a change in the esophageal mucosa as a result of long-standing gastroesophageal reflux disease. The importance of BE is that it is the main risk factor for the development of esophageal adenocarcinoma, whose incidence is currently growing faster than any other cancer in the Western world. The aim of this review was to compare the common treatment modalities of BE, with the focus on proton pump inhibitors and operative fundoplication. We performed a literature search on medical and surgical treatment of BE to determine eligible studies for this review. Studies on medical and surgical treatment of BE are discussed with regard to treatment effect on progression and regression of disease. Although there is some evidence for control of reflux with either medical or surgical therapy, there is no def initive evidence that either treatment modality decreases the risk of progression to dysplasia or cancer. Even though there is a trend toward antireflux surgery being superior, there are no def initive studies to prove this.
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第30期3773-3779,共7页 世界胃肠病学杂志(英文版)
关键词 Barrett’s esophagus Intestinal METAPLASIA Proton pump inhibitors NISSEN FUNDOPLICATION Esophageal adenocarcinoma GASTROESOPHAGEAL REFLUX Barrett’s esophagus Intestinal metaplasia Proton pump inhibitors Nissen fundoplication Esophageal adenocarcinoma Gastroesophageal reflux
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参考文献41

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二级参考文献11

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