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内质网应激 被引量：12

Endoplasmic Reticulum (ER) Stress
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摘要 内质网应激(ER stress)是真核细胞的一种保护性应激反应,通过ER stress细胞降低胞内未折叠蛋白的浓度,阻碍未折叠蛋白发生凝集,哺乳动物细胞ER stress过程比原生动物和酵母细胞要复杂,但都具有一些共同的特点。 Endoplasmic reticulum (ER) stress is a protective stress reaction by eukaryotes. Conditions interfering with endoplasmic reticulum ( ER) function will perturb the folding of newly synthesized membrane or secreted proteins. The accumulation of unfolded proteins in ER causes cells' ER stress response, which reduces the amount and aggregation of unfolded proteins in ER. Mammals have more complicated response process than yeasts and protozoa, but they share some characteristics in this regard.
作者 方欢 申宗候
机构地区 复旦大学上海医学院生化与分子生物学系
出处 《医学分子生物学杂志》 CAS CSCD 2004年第1期36-39,共4页 Journal of Medical Molecular Biology
关键词 内质网应激 非折叠蛋白反应 真核细胞 保护性应激反应 信号传导 ER stress unfolded protein response ATF6 PERK Irel
分类号 R363.27 [医药卫生—病理学]
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参考文献18

  • 1Kokame K,Kato H,Miyata T.Identification of ERSE-II,a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response.J Biol Chem,2001,276(12):9 199-205.
  • 2Kaufman RJ.Stress signaling from the lumen of the endoplasmic reticulum:coordination of gene transcriptional and translational controls.Gene Dev,1999,13:1 211-33.
  • 3Shen J,Chen X,Hendershot L,et al.Prywes R.ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals.Dev Cell,2002,3(1):99-111.
  • 4Lee AH,Iwakoshi NN,Glimcher LH.XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response.Mol Cell Biol,2003,23(21):7 448-59.
  • 5Wang Y,Shen J,Arenzana N,et al.Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.J Biol Chem,2000,275(35):27 013-20.
  • 6Yoshida H,Matsui T,Yamamoto A,et al.XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.Cell,2001,107(7):881-91.
  • 7Brewer JW,Diehl JA.PERK mediates cell-cycle exit during the mammalian unfolded protein response.Proc Natl Acad Sci USA,2000,97(23):12625-30.
  • 8McCullough KD,Martindale JL,Klotz LO,et al.Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state.Mol Cell Biol,2001,21(4):1 249-59.
  • 9Rao RV,Hermel E,Castro-Obregon S,et al.Coupling endoplasmic reticulum stress to the cell death program.Mechanism of caspase activation.J Biol Chem,2001,276(36):33 869-74.
  • 10Morishima N,Nakanishi K,Takenouchi H,et al.An endoplasmic reticulum stress-specific caspase cascade in apoptosis.Cytochrome c-independent activation of caspase-9 by caspase-12.J Biol Chem,2002,277(37):34 287-94.

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医学分子生物学杂志
2004年 第1期

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