摘要
目的建立4种抗氧剂(无水亚硫酸钠、亚硫酸氢钠、焦亚硫酸钠和硫代硫酸钠)的细菌内毒素检查方法。方法按中国药典2005年版二部附录收载的细菌内毒素检查方法进行实验。结果4种抗氧剂在200μg.mL-1浓度以下对鲎试剂无干扰作用。细菌内毒素限值订为2.5EU.mg-1。结论这4种抗氧剂采用细菌内毒素检查方法是可行的。
OBJECTIVE To establish the quality standard for the bacterial endotoxins test of four antioxidants(anhydrous sodium sulfite,sodium bisulfite,sodium pyrosulfite and sodium thiosulfate).METHODS The test was operated according to the method for examination of bacterial endotoxin test in Ch.P(2005)Vol II.RESULTS The four antioxidants did not interfere with TAL reagent under the concentration of 200 μg·mL-1.The appropriate limit of endotoxin was 2.5 EU·mg-1.CONCLUSION It was feasible to use this method in the examination of the four antioxidants.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2009年第S1期1153-1154,共2页
Chinese Journal of Modern Applied Pharmacy
关键词
无水亚硫酸钠
亚硫酸氢钠
焦亚硫酸钠
硫代硫酸钠
细菌内毒素
anhydrous sodium sulfite
sodium bisulfite
sodium pyrosulfite,sodium thiosulfate
bacterial endotoxin
