摘要
目的观察不同浓度三效愈创软膏对二甲苯小鼠炎症模型、体外各种菌株、肺炎球菌小鼠模型的影响。方法建立二甲苯小鼠炎症模型,体外各种菌株、肺炎球菌小鼠模型,采取随机对照的方法,检测经不同浓度三效愈创软膏作用后小鼠耳廓肿胀程度、小鼠耳廓毛细血管通透性、多种菌株生长状况和肺炎球菌小鼠死亡率的变化。结果8%三效愈创软膏组对二甲苯引起的小鼠耳廓肿胀具有明显的抑制作用,与京万红相比无统计学意义;可显著抑制二甲苯所致的鼠耳毛细血管通透性;对大肠杆菌、金黄色葡萄球菌、绿脓杆菌、宋内氏痢疾杆菌、伤寒杆菌均有不同程度的抑制或杀灭作用;显著降低腹腔感染肺炎双球菌小鼠的死亡率。结论三效愈创软膏具有较好的抗炎、体内外抑菌作用。
Objective To observe the effects of Sanxiaoyuchuang ointment on the mice inflammatory model induced by Dimethylbenzene,bacteria strains in vitro and mice pneumococcus pneumonia model.Methods Mice inflammatory model induced by Dimethylbenzene,in vitro bacteria strains model and mice pneumococcus pneumonia model were founded respectively,randomed and controlled methods were used,exposed to different dosages of Sanxiaoyuchuang ointment,the changes of auricle swelling degree,earcapillary vessel permeability,the growth rate of strains and pneumococcus pneumonia mice's mortality were measured.Results 8% dose Sanxiaoyuchuang group had obvious inhibition effects on mice auricle swelling induced by Dimethylbenzene,it had no obvious difference compared with Jingwanhong group.It could also lower the mice earcapillary vessel permeability,inhibit or eradicate the colon bacillus,Staphylococcus aureus,cyanomycosis,Sonne dysetery,typhoid bacillus,and decrease the mortality rate of mice intraperitoneal injected by pneumococcus.Conclusion Sanxiaoyuchuang ointment has good antiinflammatory and bacteriostasis(in vivo and in vitro) pharmacodynamics effects.
出处
《中国中医药信息杂志》
CAS
CSCD
2009年第S1期22-23,132,共3页
Chinese Journal of Information on Traditional Chinese Medicine
关键词
三效愈创软膏
抗炎抑菌
动物模型
清热解毒
Sanxiaoyuchuang ointment
anti-inflammatory and bacteriostasis
animal model
clearing away heat and toxic material
