摘要
目的探讨血清半胱氨酸蛋白酶抑制剂C(Cystatin C)与原发性高血压靶器官损伤的关系。方法以原发性高血压患者60例为研究对象,采用颗粒增强透射免疫比浊法测量Cystatin C水平,超声波图像评估左心室质量指数(LVMI),无创性袖带式动态血压监测仪测量24 h血压(24 h-BP)。结果血清Cystatin C水平与肌酐清除率、尿微量白蛋白、24 h平均收缩压(24 h-SBP)、LVMI均相关。尿白蛋白排泄率(AER)及血清Cystatin C水平与平均24 h-SBP独立相关。AER与高密度脂蛋白胆固醇相关,而Cystatin C与之不相关。结论血清Cystatin C水平是原发性高血压患者靶器官损伤严重性的一个早期标志。
Objective To observe the role of serum Cystatin C on organ damage in patients with essential hypertension.Methods Sixty patients with essential hypertension were included in the study.Serum Cystatin C level was measured by using particle-enhanced turbidimetric assay.Left ventricular mass index(LVMI) was evaluated by using ultrasound images.Cuff-oscillometric method was adopted to measure 24-hour blood pressure.Results Serum Cystatin C level was correlated with creatinine clearance,urine microamoun albuminuria,mean 24 h systolic blood pressure(24 h-SBP) and LVMI.Both albumin excretion rate(AER) and serum Cystatin C level were independently correlated with mean 24 h-SBP.AER was correlated with HDL-cholesterol.Conlusion Serum Cystatin C level is an early marker to predict the severity of end-organ damage in patients with essential hypertension.
出处
《山东医药》
CAS
北大核心
2009年第52期37-39,共3页
Shandong Medical Journal
