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万古霉素与利奈唑胺治疗MRSA菌血症疗效比较 被引量:3

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摘要 目的比较万古霉素与利奈唑胺治疗耐甲氧西林金黄色葡萄球菌(MRSA)菌血症的效果和安全性。方法将14例MRSA菌血症患者随机分为两组,分别给予万古霉素治疗(A组,n=8)和利奈唑胺治疗(B组,n=6)。观察2种药物治疗后临床效果及药物不良反应。结果两组第28天病死率、细菌清除率、血管活性药物使用时间的差异无统计学意义(P>0.05)。治疗后A组退热时间及细菌清除时间较B组缩短(P<0.05),入住ICU时间延长(P<0.05)。两组治疗后白细胞、中性粒细胞比值、C反应蛋白、降钙素原结果均较治疗前下降,但组间比较差异无统计学意义(P>0.05)。A组治疗后内生肌酐清除率较治疗前下降(P<0.05),第14天恢复到治疗前水平。结论利奈唑胺与万古霉素治疗MRSA疗效相当,且两种药物的安全性、耐受性较好。
出处 《山东医药》 CAS 北大核心 2009年第52期69-70,共2页 Shandong Medical Journal
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