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PDGF调节因子及其信号转导通路与肺纤维化 被引量:2

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摘要 肺纤维化是多种原因引起的异质性疾病,主要病理特点是早期的弥漫性肺泡炎和后期大量成纤维细胞病理性增生及基质胶原进行性积聚并取代正常的肺组织结构。已有充分证据显示TGF-β、CTGF、PDGF等细胞因子能促进肺成纤维细胞分裂增殖,对成纤维细胞具有趋化作用,调节胶原蛋白的合成与降解,与肺纤维化的发生发展关系密切。
出处 《现代预防医学》 CAS 北大核心 2008年第S1期68-69,共2页 Modern Preventive Medicine
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