摘要
目的 探讨喉癌病人外周血T淋巴细胞亚群和红细胞免疫功能状况及其在病情估计、疗效观察及预后估测中的意义。方法 对不同情况的61例喉癌病人,进行外周血T淋巴细胞亚群和红细胞免疫功能的检测,38例喉癌病人治疗后进行了5年的随访。结果 喉癌病人外周血T淋巴细胞亚群CD4+和CD4+/CD8+比值下降,CD8+升高,红细胞C3b受体花环率和红细胞免疫复合物花环率降低(P<0.01);晚期喉癌病人CD4+/CD8+比值较早期病人低(P<0.01);T淋巴细胞亚群、红细胞免疫等指标均与疗效有关(P<0.05-0.01);CD4+/CD8+比值与病人的5年生存情况有关(P<0.01)。结论 喉癌病人细胞免疫功能和红细胞免疫功能降低,复发或转移者更低。CD4+/CD8+比值对喉癌的预后具有重要的临床意义。
Objective To study the clinical significance of the determination of the peripheral T-lymphocyte subpopulations and red-cell immunology in patients with laryngeal carcinoma. Methods Peripheral blood T-lymphocyte subpopulations and red-cell immunology were determined in 61 patients with laryngeal carcinoma in different conditions,and the thirty-eight patients were with follow-up at least five years. Results For the patients of laryngeal carcinoma,the percentage of CD4+ and the ratio CD4+/CD8+ ,and also,the rosette rates of the red cell C3b receptor and red cell immune complex were statistically significantly decreased (P<0. 01). The levels of the ratio CD4+/CD8+ were decreased in advanced patients compared with early-stage patients (P<0. 01). The peripheral T-lymphocyte subpopulations and red-cell immunology were concerned with the curative effects of the patients with laryngeal carcinoma (P<0. 05-0. 01). The ratios of CD4+/CD8+ were related to the 5-year-survival rates of the patients (P<0. 01). Conclusions Both the cell immunology and red-cell immunology were significantly decreased in the patients with laryngeal carcinoma, and more serious in the recurrence patients. The results suggested that the ratio CD4+/CD8+ had certain clinical significance in monitoring prognosis of the patients with laryngeal carcinoma.
出处
《青岛医药卫生》
2003年第3期162-165,共4页
Qingdao Medical Journal
关键词
喉肿瘤
癌
鳞状细胞
细胞免疫
红细胞
Laryngeal neoplasms Carcinoma Squamous cell Cellular immunity Erythorcytes
